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GDNF Protein, Human, Recombinant

GDNF Protein, Human, Recombinant

产品编号 TMPY-06970
别名: ATF1, ATF2, HSCR3, 胶质细胞生长因子, HFB1-GDNF, glial cell derived neurotrophic factor

GDNF Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15.2 kDa and the accession number is P39905-1.

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GDNF Protein, Human, Recombinant
规格 价格/CNY 货期 数量
20 μg ¥ 1,950 5日内发货
100 μg ¥ 4,920 5日内发货
1 mg ¥ 28,800 5日内发货
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产品目录号及名称: GDNF Protein, Human, Recombinant (TMPY-06970)
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生物活性
技术参数
产品性质
参考文献
生物活性 Measured in a cell proliferation assay using SH‑SY5Y human neuroblastoma cells. The ED50 for this effect is typically 1-5 ng/mL in the presence of Recombinant Human GFR alpha‑1/GDNF R alpha‑1 His Chimera.
产品描述 GDNF Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15.2 kDa and the accession number is P39905-1.
种属 Human
表达系统 E. coli
标签 Tag Free
蛋白编号 P39905-1
别名 ATF1, ATF2, HSCR3, 胶质细胞生长因子, HFB1-GDNF, glial cell derived neurotrophic factor
蛋白构建 Human GDNF (P39905-1) (Ser78-Ile211)
蛋白纯度 ≥ 95 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC.
分子量 15.2 kDa (predicted)
内毒素 < 10 EU/mg of the protein.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing 30% acetonitrile, 1/1000 TFA. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法 A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice.

研究背景 Glial cell line-derived neurotrophic factor(GDNF) is an important member of the GDNF family of ligands(GFL). The GDNF family of ligands is comprised by four neurotrophic factors: glial cell line-derived neurotrophic factor (GDNF), neurturin (NRTN), artemin (ARTN), and persephin (PSPN). It has been found that GFLs play a role in a number of biological processes including cell survival, neurite outgrowth, cell differentiation and cell migration. As the founding member, GDNF plays a key role in the promotion of the survival of dopaminergic neurons. GDNF is a highly conserved neurotrophic factor. The recombinant form of this protein also promotes the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. GDNF also regulates kidney development and spermatogenesis, and it affects alcohol consumption. It has been shown that GDNF results in two Parkinson's disease clinical trial and in a number of animal trials. It has been taken as a potent survival factor for central motoneurons.

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Keywords

GDNF Protein, Human, Recombinant ATF1 ATF 1 ATF-1 ATF 2 HSCR 3 ATF2 HSCR-3 ATF-2 HSCR3 胶质细胞生长因子 HFB1-GDNF glial cell derived neurotrophic factor recombinant recombinant-proteins proteins protein

 

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