CYP2C9 Protein, Human, Recombinant (His & Myc)

产品编号 TMPH-01186

CYP2C9 Protein, Human, Recombinant (His & Myc) is expressed in E. coli.

CYP2C9 Protein, Human, Recombinant (His & Myc)

产品编号 TMPH-01186

CYP2C9 Protein, Human, Recombinant (His & Myc) is expressed in E. coli.

规格	价格	库存
20 μg	¥ 1,800	20日内发货
100 μg	¥ 3,760	20日内发货
1 mg	¥ 16,000	20日内发货

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产品信息

生物活性	Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
产品描述	CYP2C9 Protein, Human, Recombinant (His & Myc) is expressed in E. coli.
种属	Human
表达系统	E. coli
标签	N-10xHis, C-Myc
蛋白编号	P11712
别名	S-mephenytoin 4-hydroxylase,Cytochrome P-450MP,Cytochrome P450 PB-1,Cytochrome P450 MP-8,Cytochrome P450 MP-4,Cytochrome P450 2C9,CYPIIC9,CYP2C9,CYP2C10,Cholesterol 25-hydroxylase,(S)-limonene 7-monooxygenase,(S)-limonene 6-monooxygenase,(R)-limonene 6-monooxygenase
氨基酸序列	MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKGG
蛋白构建	1-162 aa
蛋白纯度	> 85% as determined by SDS-PAGE.
分子量	25.4 kDa (predicted)
内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Tris-based buffer, 50% glycerol
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
研究背景	A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids and steroids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA). Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis. Exhibits low catalytic activity for the formation of catechol estrogens from 17beta-estradiol (E2) and estrone (E1), namely 2-hydroxy E1 and E2. Catalyzes bisallylic hydroxylation and hydroxylation with double-bond migration of polyunsaturated fatty acids (PUFA). Also metabolizes plant monoterpenes such as limonene. Oxygenates (R)- and (S)-limonene to produce carveol and perillyl alcohol. Contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan.