Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Denzimol 是一种新型抗惊厥化合物。Denzimol 对强直性癫痫发作具有选择性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 630 | 现货 | ||
5 mg | ¥ 1,430 | 现货 | ||
10 mg | ¥ 2,130 | 现货 | ||
25 mg | ¥ 3,620 | 现货 | ||
50 mg | ¥ 5,220 | 现货 | ||
100 mg | ¥ 7,380 | 现货 | ||
500 mg | ¥ 14,700 | 现货 |
产品描述 | Denzimol is a novel anticonvulsant compound.Denzimol is selective for tonic seizures. |
体内活性 | Denzimol (30 mg/kg; p.o.; 14 days; mice) reduced brain concentration and anticonvulsant activity compared with non-treated mice, and t1/2 beta was significantly changed from 2.10 to 1.53 hr. Tonic hindlimb extension was completely abolished at a brain denzimol concentration higher than 15 mcg/g, whereas the minimum effective brain concentration was between 2-3 mcg/g both in acute and repeatedly treated animals. The brain concentration of denzimol is closely correlated with its anticonvulsant effect both in acute and repeatedly treated animals. Furthermore, these findings seem to suggest that the decreased anticonvulsant activity of denzimol, following repeated administrations, might be due to a development of pharmacokinetic tolerance.[4] |
分子量 | 292.37 |
分子式 | C19H20N2O |
CAS No. | 73931-96-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 16.67 mg/mL (57.01 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.4203 mL | 17.1016 mL | 34.2032 mL | 85.5081 mL |
5 mM | 0.6841 mL | 3.4203 mL | 6.8406 mL | 17.1016 mL | |
10 mM | 0.342 mL | 1.7102 mL | 3.4203 mL | 8.5508 mL | |
20 mM | 0.171 mL | 0.8551 mL | 1.7102 mL | 4.2754 mL | |
50 mM | 0.0684 mL | 0.342 mL | 0.6841 mL | 1.7102 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Denzimol 73931-96-1 Others Inhibitor inhibitor inhibit