Name: Cobolimab
Brand: TargetMol
SKU: T77149
Price: 2480 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 2,480

现货

5 mg

¥ 5,860

现货

10 mg

¥ 7,890

现货

25 mg

¥ 11,700

现货

50 mg

¥ 15,800

现货

生物活性

产品描述	Cobolimab (TSR-022) is a potent monoclonal antibody to TIM-3. Cobolimab induces internalization of TIM-3 with an IC50 value of 0.4464 nM. Cobolimab has antitumor activity and can be used to study advanced/metastatic melanoma and advanced hepatocellular carcinoma.
靶点活性	TIM3:0.4464 nM
体外活性	Cobolimab（0.0001-10 nM；3天）在预先激活的T细胞中促进TIM-3的剂量依赖性内吞作用，IC50值为0.4464 nM[4]。Cobolimab（20 µg/mL；24小时）通过抑制TIM-3显著增加CD8+ T细胞的含量[3]。
别名	考伯利单抗, TSR-022, GSK4069889
反应种属	Human
验证活性	Immobilized Human TIM-3/KIM-3/HAVCR2 Protein (His) (TMPY-01621) at 1 μg/mL (100 μL/well) can bind Cobolimab. The EC50 is 5.13 ng/mL.
应用	ELISA FCM Functional assay
抗体种类	Monoclonal
缓冲液	Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
内毒素	<1.0 EU/mg

抗体信息

同型	Human IgG4SP kappa
推荐同型对照	Human IgG4 (S228P) kappa, Isotype Control

偶联与修饰

偶联	Unconjugated

抗原信息

化学信息

分子量	142.84 kDa
CAS No.	2022215-65-0

储存&溶解度

存储	Shipping with blue ice/Shipping at ambient temperature. 实际储存温度请以COA为准

Cobolimab