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Anti-p53 Antibody (5M213)
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还可以产品编号 TMAC-02992
Anti-p53 Antibody (5M213) 是一种 Rabbit 抗体，靶向 p53。Anti-p53 Antibody (5M213) 可用于 FCM,ICC,IF,IHC,IP,WB。
Anti-p53 Antibody (5M213)
Anti-p53 Antibody (5M213)
一键复制产品信息 还可以产品编号 TMAC-02992
Anti-p53 Antibody (5M213) 是一种 Rabbit 抗体，靶向 p53。Anti-p53 Antibody (5M213) 可用于 FCM,ICC,IF,IHC,IP,WB。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,490 | 5日内发货 | |
| 100 μL | ¥ 2,490 | 5日内发货 |
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| 产品描述 | Anti-p53 Antibody (5M213) is a Rabbit antibody targeting p53. Anti-p53 Antibody (5M213) can be used in FCM,ICC,IF,IHC,IP,WB. |
| Ig Type | IgG |
| 克隆号 | 5M213 |
| 交叉反应 | Human |
| 验证活性 | 1. Western blot analysis of p53 on 293 cell using p53 antibody at 1/500 dilution. 2. Immunohistochemical analysis of paraffin-embedded human stomach cancer tissue using p53 antibody. Counter stained with hematoxylin. 3. Immunohistochemical analysis of paraffin-embedded human breast cancer tissue using p53 antibody. Counter stained with hematoxylin. 4. Flow cytometric analysis of Daudi cells with p53 antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti-rabbit IgG was used as the secondary antibody.     |
| 应用 | FCMICCIFIHCIPWB |
| 推荐剂量 | WB: 1:500; IHC: 1:100; ICC: 1:100-500; FCM: 1:50-100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | ProA affinity purified |
| 性状 | Liquid |
| 缓冲液 | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| 研究背景 | Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein |
| Uniprot ID |
| 分子量 | Theoretical: 53 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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