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Anti-NQO1 Antibody (3R649)
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产品编号 TMAC-02885
别名 QR1, NMORI, NMOR1, NAD(P)H dehydrogenase, quinone 1, DTD, DIA4, DHQU
Anti-NQO1 Antibody (3R649) 是一种 Rabbit 抗体，靶向 NQO1。Anti-NQO1 Antibody (3R649) 可用于 WB,ICC/IF,IP,FCM。
Anti-NQO1 Antibody (3R649)
Anti-NQO1 Antibody (3R649)
还可以产品编号 TMAC-02885 别名 QR1, NMORI, NMOR1, NAD(P)H dehydrogenase, quinone 1, DTD, DIA4, DHQU
Anti-NQO1 Antibody (3R649) 是一种 Rabbit 抗体，靶向 NQO1。Anti-NQO1 Antibody (3R649) 可用于 WB,ICC/IF,IP,FCM。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,485 | 5日内发货 | |
| 100 μL | ¥ 2,480 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
化学信息
| 产品描述 | Anti-NQO1 Antibody (3R649) is a Rabbit antibody targeting NQO1. Anti-NQO1 Antibody (3R649) can be used in WB,ICC/IF,IP,FCM. |
| 别名 | QR1, NMORI, NMOR1, NAD(P)H dehydrogenase, quinone 1, DTD, DIA4, DHQU |
| Ig Type | IgG |
| 交叉反应 | Human,Mouse,Rat |
| 验证活性 | 1. Western blot analysis of NQO1 on different lysates using anti-NQO1 antibody at 1/1,000 dilution. Positive control: Lane 1: SH-SY-5Y, Lane 2: Mouse kidney, Lane 3: Raji. 2. Flow cytometric analysis of Hela cells with NQO1 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody. |
| 应用 | |
| 推荐剂量 | WB: 1:1000-5000; ICC/IF: 1:50-200; IP: 1:50; FCM: 1:50-100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | ProA affinity purified |
| 性状 | Liquid |
| 缓冲液 | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| 研究背景 | NAD(P)H:quinone oxidoreductase 1 (NQO1) and NRH:quinone oxidoreductase (NQO2) are flavoproteins that catalyze the metabolic detoxification of quinones and their derivatives to hydroquinones, using either NADH or NADPH as the electron donor. This protects cells against quinone-induced oxidative stress, cytotoxicity, and mutagenicity. Many tumors overexpress NQO1, which is an obligate two-electron reductase that deactivates toxins and activates bioreductive anticancer drugs. NQO1, a 274 amino acid protein, is ubiquitously expressed, but the expression level varies among tissues. NQO1 gene expression is coordinately induced in response to xenobiotics, antioxidants, heavy metals and radiation. The antioxidant response element (ARE) in the NQO1 gene promoter is essential for expression and coordinated induction of NQO1. ARE activation by tert-butylhydroquinone is dependent on PI3-kinase, which lies upstream of Nrf2. Nrf2, c-Jun, Nrf1, Jun-B and Jun-D bind to the ARE and regulate expression and induction of NQO1 gene. Maf-Maf homodimers and possibly Maf-Nrf2 heterodimers play a role in negative regulation of ARE-mediated transcription, but Maf-Nrf1 heterodimers fail to bind with the NQO1 gene ARE and do not repress NQO1 transcription. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein |
| Uniprot ID |
| 分子量 | Theoretical: 31/27 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
计算器
比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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