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Anti-AURKA Antibody (3R600)
还可以产品编号 TMAH-00096
Anti-AURKA Antibody (3R600) 是一种抗体，靶向 AURKA。Anti-AURKA Antibody (3R600) 可用于 ELISA, IF。
Anti-AURKA Antibody (3R600)
Anti-AURKA Antibody (3R600)
还可以产品编号 TMAH-00096
Anti-AURKA Antibody (3R600) 是一种抗体，靶向 AURKA。Anti-AURKA Antibody (3R600) 可用于 ELISA, IF。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,300 | 5日内发货 | |
| 100 μL | ¥ 2,180 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-AURKA Antibody (3R600) is an antibody targeting AURKA. Anti-AURKA Antibody (3R600) can be used in ELISA, IF. |
| Ig Type | Rabbit IgG |
| 克隆号 | 3R600 |
| 交叉反应 | Human |
| 验证活性 | Immunofluorescence staining of Hela Cells with TMAH-00096 at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeated by 0.2% TritonX-100, and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L). |
| 应用 | ELISA, IF |
| 推荐剂量 | IF:1:20-1:200. |
| 抗体种类 | Monoclonal |
| 亚细胞定位 | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cell projection, neuron projection. |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Important for microtubule formation and/or stabilization. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and destabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis. Regulates protein levels of the anti-apoptosis protein BIRC5 by suppressing the expression of the SCF(FBXL7) E3 ubiquitin-protein ligase substrate adapter FBXL7 through the phosphorylation of the transcription factor FOXP1. |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic peptide: Human Aurora A |
| 抗原种属 | Human |
| 基因ID | 6790 |
| Uniprot ID | |
| 研究领域 | Epigenetics and Nuclear Signaling, Cancer, Cell biology, Signal transduction |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
SCI 文献
计算器
比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
关键词
STK6STK15STK 6STK 15Serine/threonine-protein kinase Ayk1Serine/threonine-protein kinase aurora-ASerine/threonine-protein kinase 6Serine/threonine-protein kinase 15Ipl1- and aurora-related kinase 1IAK1IAK 1BTAKBreast tumor-amplified kinaseAYK1AYK 1Aurora2Aurora/IPL1-related kinase 1 (ARK-1;Aurora-related kinase 1)Aurora kinase-AAurora kinase AAurora 2AURKAAURAARK-1ARK1ARK 1AIRK1AIRK 1AIK
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