Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Razoxane 是拓扑异构酶 II 的有效抑制剂,具有抗血管生成的作用,在肾细胞癌中具有研究价值。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,330 | 现货 | ||
5 mg | ¥ 2,730 | 现货 | ||
10 mg | ¥ 3,830 | 现货 | ||
25 mg | ¥ 6,160 | 现货 | ||
50 mg | ¥ 8,480 | 现货 | ||
100 mg | ¥ 11,300 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 2,320 | 现货 |
产品描述 | Razoxane is used as an antimitotic agent with immunosuppressive properties. |
体内活性 | This tumor model is characterized by osteoid formation and spontaneous metastasization to lungs, kidneys and lymph nodes. Razoxane given intraperitoneally (i.p.) from 2 days before to 14 days after tumor transplantation (30 mg/kg or 10 mg/kg per day) resulted in a dose-dependent prolongation of median survival time (83 or 48 days respectively, versus 38 days for the control group), but showed no influence on the growth of the primary tumor. Early treatment with razoxane (30 mg/kg i.p. from day -2 to +14) showed a greater inhibition of pulmonary metastases than later treatment (30 mg/kg i.p. from day +14 to +28 after transplantation). Whereas 59.9 per cent of the total sectional area of the lungs in the control animals was covered by osteosarcoma metastases, only 3.4 per cent and 26.1 per cent respectively was affected in the early and late razoxane treatment groups. Toxic side-effects of these treatment schedules were reversible diffuse alopecia, but no retardation of body weight gain[2]. |
分子量 | 268.27 |
分子式 | C11H16N4O4 |
CAS No. | 21416-67-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/ml (223.66 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.7276 mL | 18.6379 mL | 37.2759 mL | 93.1897 mL |
5 mM | 0.7455 mL | 3.7276 mL | 7.4552 mL | 18.6379 mL | |
10 mM | 0.3728 mL | 1.8638 mL | 3.7276 mL | 9.319 mL | |
20 mM | 0.1864 mL | 0.9319 mL | 1.8638 mL | 4.6595 mL | |
50 mM | 0.0746 mL | 0.3728 mL | 0.7455 mL | 1.8638 mL | |
100 mM | 0.0373 mL | 0.1864 mL | 0.3728 mL | 0.9319 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Razoxane 21416-67-1 DNA Damage/DNA Repair Topoisomerase ICRF 159 ICRF159 ICRF-159 Topoisomerase II Inhibitor RCC Inhibitor renal cell carcinoma inhibit inhibitor