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KS370G

KS370G

产品编号 T24270   CAS 105955-01-9
别名: KS-370-G, KS 370 G, Caffeic Acid Phenethyl Amide

KS370G (Caffeic Acid Phenethyl Amide) 抑制 UUO 诱导的肾纤维化标志物表达。KS370G 是一种具有口服活性的降糖和心血管保护剂,可减少梗阻肾脏中胶原蛋白的沉积,并显著降低肾脏炎症趋化因子/粘附分子和单核细胞标志物的表达,改善压力过载小鼠心脏左室肥厚和功能。KS370G 可用于研究肾阻塞性肾病。

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KS370G Chemical Structure
KS370G, CAS 105955-01-9
规格 价格/CNY 货期 数量
1 mg ¥ 483 现货
5 mg ¥ 1,100 现货
10 mg ¥ 1,630 现货
25 mg ¥ 2,800 现货
50 mg ¥ 4,160 现货
100 mg ¥ 5,930 现货
500 mg ¥ 12,200 现货
药物设计专题培训
千万补贴 助力科研
BCA蛋白浓度测定试剂盒限时半价
重组蛋白限时优惠
产品目录号及名称: KS370G (T24270)
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纯度: 99.51%
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生物活性
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存储 & 溶解度
参考文献
产品描述 KS370G (Caffeic Acid Phenethyl Amide) inhibits UUO-induced renal fibrosis marker expression. KS370G is an orally active hypoglycemic and cardioprotective agent that reduces collagen deposition in obstructed kidneys and significantly decreases renal expression of inflammatory chemokines/adhesion molecules and monocyte markers and improves left ventricular hypertrophy and function in the heart of pressure-overloaded mice.KS370G can be used to study renal obstructive nephropathy.
靶点活性 NO:0.44 μM(EC50)
体外活性 KS370G (0.35、1.05、1.75、3.5 uM) significantly inhibited the release of nitric oxide (NO) and the expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Treatment with KS370G also induced heme oxygenase (HO)-1 and suppressors of cytokine signaling (SOCS)-3 expression in the microglia. Furthermore, the anti-inflammatory effects of KS370G were found to be regulated by phosphorylated adenosine monophosphate-activated protein kinase-α (AMPK-α) translocated to the nucleus. Moreover, KS370G showed significant anti-neuroinflammatory effects on microglial activation in vivo and on motor behavior as well.[3]
体内活性 KS370G 1mg/kg (1mg/kg; chronic oral gavage; once a day) inhibited cardiac hypertrophy and improved cardiac function induced by pressure overload. KS370G also decreased the plasma levels of atrial natriuretic peptide and lactate dehydrogenase. Besides, pressure overload-induced increases of α-SMA and phosphorylation of ERK, AKT, and GSK3β were significantly reduced by chronic oral treatment with KS370G. We also found that chronic oral treatment with KS370G reduced cardiac collagen accumulation. KS370G improved left ventricular function and inhibited cardiac hypertrophy through the decrease of the phosphorylation of ERK, AKT, and GSK3β in pressure-overload mice hearts.[4]
别名 KS-370-G, KS 370 G, Caffeic Acid Phenethyl Amide
分子量 283.32
分子式 C17H17NO3
CAS No. 105955-01-9

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 45 mg/mL (158.83 mM)

溶液配制表

可选溶剂 浓度 体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5296 mL 17.6479 mL 35.2958 mL 88.2394 mL
5 mM 0.7059 mL 3.5296 mL 7.0592 mL 17.6479 mL
10 mM 0.353 mL 1.7648 mL 3.5296 mL 8.8239 mL
20 mM 0.1765 mL 0.8824 mL 1.7648 mL 4.412 mL
50 mM 0.0706 mL 0.353 mL 0.7059 mL 1.7648 mL
100 mM 0.0353 mL 0.1765 mL 0.353 mL 0.8824 mL

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TargetMol Library Books参考文献

1. Chuang ST, et al. KS370G, a caffeamide derivative, attenuates unilateral ureteral obstruction-induced renal fibrosis by the reduction of inflammation and oxidative stress in mice. Eur J Pharmacol. 2015 Mar 5;750:1-7. 2. Chuang ST, et al. Antifibrotic effects of KS370G, a caffeamide derivative, in renal ischemia-reperfusion injured mice and renal tubular epithelial cells. Sci Rep. 2014 Jul 24;4:5814. 3. Lu DY, et al. Anti-neuroinflammatory effect of a novel caffeamide derivative, KS370G, in microglial cells. Mol Neurobiol. 2013 Dec;48(3):863-74. 4. Weng YC, et al. KS370G, a synthetic caffeamide derivative, improves left ventricular hypertrophy and function in pressure-overload mice heart. Eur J Pharmacol. 2012 Jun 5;684(1-3):108-15. 5. Ho YJ, et al. Caffeic acid phenethyl amide ameliorates ischemia/reperfusion injury and cardiac dysfunction in streptozotocin-induced diabetic rats. Cardiovasc Diabetol. 2014;13:98.

相关化合物库

该产品包含在如下化合物库中:
经典已知活性库 已知活性化合物库

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母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

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Keywords

KS370G 105955-01-9 KS-370-G KS 370 G Caffeic Acid Phenethyl Amide Inhibitor inhibitor inhibit

 

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