Powder: -20°C for 3 years | In solvent: -80°C for 1 year
HQ-415 is a class of clinically relevant bioactive metal chelators related to clioquinol. The effective concentration eliciting an EC50 for HQ-415 is 15 μM.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 1,890 | 5日内发货 | ||
5 mg | ¥ 2,890 | 5日内发货 | ||
25 mg | ¥ 9,620 | 6-8周 | ||
50 mg | ¥ 12,500 | 6-8周 | ||
100 mg | ¥ 17,500 | 6-8周 | ||
1 mL * 10 mM (in DMSO) | ¥ 2,660 | 5日内发货 |
产品描述 | HQ-415 is a class of clinically relevant bioactive metal chelators related to clioquinol. The effective concentration eliciting an EC50 for HQ-415 is 15 μM. |
体外活性 | HQ-415 is active in the TDP-43 model, but CQ was not HQ-161 and HQ-415 is retested in the dose for their ability to rescue TDP-43. HQ-415 strongly synergizes with CQ at multiple concentrations in cells expressing α-syn. CQ fails to synergize with HQ-161 and actually antagonizes HQ-161 rescuing activity, in TDP-43-expressing cells. In contrast, despite the fact that CQ was completely inactive against TDP-43, it strongly synergized with HQ-415, decreasing the EC50 from 16 to 5 μM. Both HQ-161 and HQ-415 rescue TDP-43 toxicity. In cells expressing α-syn, HQ-161, despite being inactive on its own, synergized with HQ-415, reducing the EC50 from 21 to 14 μM. |
分子量 | 415.48 |
分子式 | C25H25N3O3 |
CAS No. | 430462-93-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 5.6 mg/mL (13.48 mM), Sonication and heating are recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.4069 mL | 12.0343 mL | 24.0685 mL | 60.1714 mL |
5 mM | 0.4814 mL | 2.4069 mL | 4.8137 mL | 12.0343 mL | |
10 mM | 0.2407 mL | 1.2034 mL | 2.4069 mL | 6.0171 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
HQ-415 430462-93-4 Others HQ415 HQ 415 Inhibitor inhibitor inhibit