Powder: -20°C for 3 years In solvent: -80°C for 2 years
Darbufelone 是 PGF2α 和 LTB4 的非竞争性双重抑制剂。 Dabfilon 有效抑制 PGHS-2，对 PGHS-2 和 PGHS-1 的 Ki 为 10 μM，IC50 为 0.19 μM 和 20 μM。
| 产品描述 | Darbufelone is a non-competitive dual inhibitor of PGF2α and LTB4. Dabfilon effectively inhibits PGHS-2 with a Ki of 10 μM and IC50s of 0.19 μM and 20 μM for PGHS-2 and PGHS-1. |
| 靶点活性 | PGHS-1:20 μM , PGHS-2:0.19 μM |
| 体外活性 | Darbufelone (5 - 60 μM) increases the cell growth inhibitory effects in A549, H520 and H460 cell lines with IC50s of 20, 21 and 15 μM[2]. |
| 体内活性 | Darbufelone (80 mg/kg/day) decreases the tumor volumes in a time-dependent manner. Darbufelone (20 or 40 mg/kg/day) dos not show any significant inhibition of tumor weight. At necropsy, Darbufelone (80 mg/kg/day) reduces the tumor weight by 30.2%[2]. |
| 别名 | CI-1004, 达布非酮 |
| 分子量 | 332.46 |
| 分子式 | C18H24N2O2S |
| CAS No. | 139226-28-1 |
Powder: -20°C for 3 years In solvent: -80°C for 2 years
( < 1 mg/ml refers to the product slightly soluble or insoluble )
参考文献
剂量换算对于不同动物的给药剂量换算，您也可以参考 更多
体内实验配液计算器计算器bottom
您可能有的问题的答案可以在抑制剂处理说明中找到，包括如何准备库存溶液，如何存储产品，以及基于细胞的分析和动物实验需要特别注意的问题。
Darbufelone 139226-28-1 GPCR/G Protein Immunology/Inflammation LTR Prostaglandin Receptor CI-1004 达布非酮 Inhibitor inhibitor inhibit
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