store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
C75 是一种合成脂肪酸合酶 (FASN) 抑制剂,可抑制前列腺癌细胞 PC3 (IC50: 35 μM)。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 387 | 现货 | ||
2 mg | ¥ 556 | 现货 | ||
5 mg | 特惠询价 | 现货 | ||
50 mg | 特惠询价 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 929 | 现货 |
产品描述 | C75 is an inhibitor synthetic fatty-acid synthase (FASN) and inhibits prostate cancer cells PC3 (IC50: 35 μM). |
靶点活性 | PC3 cell:35 μM |
体外活性 | C75 (10-50 μM) reduces the growth of LNCaP spheroids in a concentration-dependent manner (IC50: 50 μM). (-)-C75 inhibits FAS activity and has a cytotoxic effect on tumor cell lines, without affecting food consumption. (+)-C75 inhibits CPT1 and produces anorexia. The differential activity of C75 enantiomers may lead to the development of potential new specific drugs for cancer and obesity [2]. |
体内活性 | C75 (i.p.) blocks fasting-induced c-Fos expression in the arcuate nucleus, lateral hypothalamic area, and paraventricular nucleus. C75 (30 mg/kg, i.p.) inhibits the food intake of mice by ≥95% within 2 h[3]. C75-treated DIO mice have a 50% greater weight loss, and a 32.9% increased production of energy because of fatty acid oxidation. C75 treatment of rodent adipocytes and hepatocytes and human breast cancer cells increases fatty acid oxidation and ATP levels by increasing CPT-1 activity, even in the presence of elevated concentrations of malonyl-CoA [4]. |
别名 | C-75 |
分子量 | 254.32 |
分子式 | C14H22O4 |
CAS No. | 218137-86-1 |
store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 75.6mg/mL (297.3mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.9321 mL | 19.6603 mL | 39.3205 mL | 98.3014 mL |
5 mM | 0.7864 mL | 3.9321 mL | 7.8641 mL | 19.6603 mL | |
10 mM | 0.3932 mL | 1.966 mL | 3.9321 mL | 9.8301 mL | |
20 mM | 0.1966 mL | 0.983 mL | 1.966 mL | 4.9151 mL | |
50 mM | 0.0786 mL | 0.3932 mL | 0.7864 mL | 1.966 mL | |
100 mM | 0.0393 mL | 0.1966 mL | 0.3932 mL | 0.983 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
C75 218137-86-1 Metabolism Fatty Acid Synthase C 75 C-75 Inhibitor inhibitor inhibit