Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ASK1-IN-2 是一种口服有活性的凋亡信号调节激酶 1 抑制剂(IC50:32.8 nM)。它可用于研究溃疡性结肠炎。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 839 | 现货 | ||
5 mg | ¥ 2,160 | 现货 | ||
10 mg | ¥ 3,460 | 现货 | ||
25 mg | ¥ 5,660 | 现货 | ||
50 mg | ¥ 7,880 | 现货 | ||
100 mg | ¥ 10,600 | 现货 | ||
500 mg | ¥ 21,300 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 2,370 | 现货 |
产品描述 | ASK1-IN-2 is a potent and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with an IC50 of 32.8 nM. ASK1-IN-2 can potentially be used as a therapeutic strategy for ulcerative colitis[1]. |
靶点活性 | ASK1:32.8 nM (IC50) |
体外活性 | ASK1-IN-2 displays potent anti-ASK1 kinase activity and strong inhibitory effect on ASK1 in AP1-HEK293 cells with inhibition rate of 95.59%[1]. |
体内活性 | ASK1-IN-2 (1 mg/kg; i.v.) shows low clearance (CL=1.38 L/h/kg) and moderate half-life (T1/2=1.45 h) in rats[1]. ASK1-IN-2 (10 mg/kg; p.o.) shows high oral exposure (AUClast=4517 h?ng/mL), 62.2% oral bioavailability and acceptable terminal half-life (T1/2=2.31 h) in rats[1]. ASK1-IN-2 (25 mg/kg; p.o. daily for 7 d) improves dextran sulphate sodium (DSS)-induced ulcerative colitis (UC) in mice[1]. ASK1-IN-2 (25 mg/kg; p.o. daily for 7 d) blocks ASK1-p38/JNK signaling pathways and reduces inflammatory cytokine levels in DSS-induced mouse colon tissues[1]. |
分子量 | 364.38 |
分子式 | C19H17FN6O |
CAS No. | 2541792-70-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 249 mg/mL (683.35 mM), Sonification is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.7444 mL | 13.7219 mL | 27.4439 mL | 68.6097 mL |
5 mM | 0.5489 mL | 2.7444 mL | 5.4888 mL | 13.7219 mL | |
10 mM | 0.2744 mL | 1.3722 mL | 2.7444 mL | 6.861 mL | |
20 mM | 0.1372 mL | 0.6861 mL | 1.3722 mL | 3.4305 mL | |
50 mM | 0.0549 mL | 0.2744 mL | 0.5489 mL | 1.3722 mL | |
100 mM | 0.0274 mL | 0.1372 mL | 0.2744 mL | 0.6861 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
ASK1-IN-2 2541792-70-3 Apoptosis MAPK ASK colitis ulcerative signal-regulating ASK1 IN 2 ASK1IN2 inhibit MAP kinase kinase kinase, MEKK, MAPKKK ASK1 Inhibitor ASK-1-IN-2 MAP3K inhibitor