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(Z)-Lanoconazole 是 Lanoconazole 的 Z 构型,用于研究皮肤癣菌病和甲癣。Lanoconazole 抑制甾醇 14-α脱甲基酶并阻断真菌膜上的麦角甾醇生物合成,从而干扰麦角甾醇的生物合成。Lanoconazole 是具有口服活性的咪唑类抗真菌剂,在体外和体内均具有广谱的抗真菌活性。
(Z)-Lanoconazole 是 Lanoconazole 的 Z 构型,用于研究皮肤癣菌病和甲癣。Lanoconazole 抑制甾醇 14-α脱甲基酶并阻断真菌膜上的麦角甾醇生物合成,从而干扰麦角甾醇的生物合成。Lanoconazole 是具有口服活性的咪唑类抗真菌剂,在体外和体内均具有广谱的抗真菌活性。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 2 mg | ¥ 522 | 5日内发货 |
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| 产品描述 | (Z)-Lanoconazole is the Z configuration of Lanoconazole which used for dermatophytosis and onychomycosis investigation. Lanoconazole inhibits sterol 14-alpha demethylase and blocks fungal membrane ergosterol biosynthesis that interferes with ergosterol biosynthesis. Lanoconazole is a potent and orally active imidazole antifungal agent with a broad spectrum of activity against fungi both in vitro and in vivo [1] [2]. |
| 体内活性 | Lanoconazole (treatment for ear; 0.3%-3%; 6 days) dose‐dependently suppressesTPA-induced irritant dermatitis, suppresses the production of neutrophil chemotactic factors such as keratinocyte‐derived chemokine and macrophage inflammatory protein-2, and inhibited neutrophil infiltration to the inflammation site [2].Lanoconazole (oral administration; 3, 10 or 30 mg/kg; once a day; 3 weeks) significantly inhibits C. neoformans compared with the saline control in normal mice. In addtion, it significantly reduces the growth of C. neoformans in the lungs and brains of MAIDS mice [3]. |
| 分子量 | 319.83 |
| 分子式 | C14H10ClN3S2 |
| Smiles | #N/A |
| 存储 | Shipping with blue ice/Shipping at ambient temperature. 实际储存温度请以COA为准 |
对于不同动物的给药剂量换算,您也可以参考 更多