sk 1071

SK1071 is a novel migrastatin analogs, which demonstrated improved performance over migrastatin, with nanomolar IC50 values in chamber cell migration assays with tumor cells and human umbilical vein endothelial cells (HUVECs), and in wound healing assays.

GSK-1071306 是帕唑帕尼(Pazopanib) 的主要人体代谢产物(M27)，属于VEGFR/PDGFR/c-Kit 酪氨酸激酶抑制剂类代谢物，本身保留弱激酶抑制活性。GSK-1071306 主要用于药代与代谢研究。