s 312

S 312 is a calcium antagonist.

Dehydrodeoxy donepezil is an inhibitor of acetylcholinesterase (AChE)

S-312d is a calcium channel antagonist. S-312-d can offer marked neuronal protective effects against ischemic injury.

CRS-3123, a methionyl-tRNA synthetase inhibitor, is used potentially for the treatment of enteric infections.

CRS3123 (REP-3123) dihydrochloride 是一种口服具有活力的全合成抗菌剂，能够有效抑制 Clostridioides difficile 甲硫氨酰-tRNA 合成酶 (MetRS)。CRS3123 dihydrochloride 能够用于 Clostridioides difficile 感染 (CDI) 的研究。

Anti-inflammatory agent 84 (Compound 4D) 是一种 Coumarin 衍生物，具有抗菌和抗炎作用。它能够抑制 E. coli、Candida albicans、Staphylococcus aureus 和 耐甲氧西林 S. aureus (MRSA)，其 MIC 分别为 312、156、19 和 316 μg/mL。此外，Anti-inflammatory agent 84 抑制 S. aureus、E. coli 和 MRSA 的生物膜形成，IC50 分别为 185、321 和 99 μM。它还可抑制 Lipopolysaccharide 刺激的 RAW264.7 巨噬细胞中一氧化氮的生成。

PAR2 (1-6) amide is a synthetic peptide agonist of proteinase-activated receptor 2 (PAR2) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of human PAR2 and residues 37-42 of the full-length sequence.1It binds to NCTC 2544 cells expressing human PAR2 (Ki= 9.64 μM in a radioligand binding assay) and induces calcium mobilization in the same cells (EC50= 0.075 μM).2PAR2 (1-6) amide (100 μM) reduces colony formation of A549 lung cancer cells.1It induces superoxide production and degranulation in isolated human eosinophils when used at a concentration of 500 μM.3PAR2 (1-6) amide (5 μmol/kg) induces tear secretion in rats when used in combination with amastatin .4 1.Bohm, S.K., Kong, W., Bromme, D., et al.Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2Biochem. J.314(Pt 3)1009-1016(1996) 2.Kanke, T., Ishiwata, H., Kabeya, M., et al.Binding of a highly potent protease-activated receptor-2 (PAR2) activating peptide, [3H]2-furoyl-LIGRL-NH2, to human PAR2Br. J. Pharmacol.145(2)255-263(2005) 3.Miike, S., McWilliam, A.S., and Kita, H.Trypsin induces activation and inflammatory mediator release from human eosinophils through protease-activated receptor-2J. Immunol.167(11)6615-6622(2001) 4.Nishikawa, H., Kawai, K., Tanaka, M., et al.Protease-activated receptor-2 (PAR-2)-related peptides induce tear secretion in rats: Involvement of PAR-2 and non-PAR-2 mechanismsJ. Pharmacol. Exp. Ther.312(2)324-331(2005)