rnf5 inhibitor inh 02

RNF5 inhibitor inh-02, a potent E3 ubiquitin ligase RNF5 RMA1 inhibitor, demonstrates significant efficacy in rescuing F508del-CFTR with an EC50 of 2.2 uM in bronchial epithelial cells homozygous for the F508del mutation. This compound is valuable for cystic fibrosis research[1].

RNF5 agonist 1 (analog-1) 是 RNF5 inhibitor inh-02 的结构类似物，也是一种有效的 RNF5 激动剂。在表达 CFBE41o- 的 F508del-CFTR 细胞中，RNF5 agonist 1 能够增加 ATG4B 的泛素化状态。