r 995045

R995045 is a novel delta opioid receptor agonist chemotype.

Albendazole-D7 is intended for use as an internal standard for the quantification of albendazole by GC- or LC-MS. Albendazole (T1152) is an orally bioavailable benzimidazole anthelmintic that is active against a variety of helminths,including liver flukes,tapeworms,and roundworms. It eliminates Trichostrongylus in the fourth stomach of cattle and sheep when orally administered at doses ranging from 2.5 to 10 mg/kg as well as other species in the fourth stomach and the small and large intestine. Albendazole (T1152) (0.05% in the diet)protects mice against lethal infection with A. suum larvae. It also inhibits growth of HT-29 human colorectal cancer cells (IC50 = 0.12 µM),halts the cell cycle at the G2/M phase,and induces apoptosis. In an HT-29 mouse xenograft model,it inhibits peritoneal tumor growth when administered intraperitoneally at a dose of 150 mg/kg but not when administered orally. Albendazole (T1152)inhibits mammalian tubulin polymerization and inhibits binding of [3H]mebendazole t......