ptp-1b-in-3

PTP1B-IN-3 是一种具有有选择性和高效性的 PTP1B 抑制剂，具有抗癌活性，抑制 PTP1B 和 TCPTP 。PTP1B-IN-3 可用于研究糖尿病。

PTP1B-IN-30 (Compound 3j) 是一种PTP1B抑制剂，其IC50为0.51 µM。PTP1B-IN-30 对癌细胞T47D的增殖具有抑制作用，IC50为21.21 µM，可导致细胞周期在S期停滞，并诱导T47D细胞凋亡 (apoptosis)。

PTP1B-IN-3 diammonium is a highly effective and orally bioavailable inhibitor of the protein tyrosine phosphatase 1B (PTP1B) enzyme, with an IC50 value of 120 nM for both PTP1B and TCPTP. This compound exhibits potent antidiabetic and anticancer properties, as supported by extensive research [1] [2].

PTP1B-IN-1 (PTP1B inhibitor) 是一种蛋白质酪氨酸磷酸酶 1B 的有效抑制剂 (IC50 : 1.6 mM)