Ebopiprant, also known as OBE-022, is an Oral and Selective Prostaglandin F 2α Receptor Antagonist as an Effective and Safe Modality for the Treatment of Preterm Labor. OBE022 exhibits potent tocolytic effects on human tissues ex vivo and animal models in vivo without causing the adverse fetal side effects seen with indomethacin.
Erlosiban, also known as OBE001, is a novel, orally active nonpeptide oxytocin receptor antagonist under development for the treatment of preterm labor and improvement in embryo implantation and pregnancy rate in assisted reproductive technology (ART).
Lipopolysaccharides, from E. coli O128:B12 (LPS, from Escherichia coli (O128:B12)) 是一种从大肠杆菌 (E. coli O128:B12) 提取的脂多糖内毒素和TLR-4激活剂,属于 S (smooth) 型 LPS。其具有典型的三部分结构:O 抗原、R3 型核心寡糖和脂质 A。Lipopolysaccharides, from E. coli O128:B12 通过激活免疫细胞的TLR-4,用于构建动物新生儿脑部炎症模型,并可能影响新生儿早产。