ph 11

PH11 is a novel Focal Adhesion Kinase (FAK) inhibitor. PH11 restores TRAIL apoptotic pathway in PANC-1 cells through down-regulation of c-FLIP via inhibition of FAK and the phosphatidylinositol-3 kinase (PI3K) AKT pathways. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) emerges as one of the most-promising experimental cancer therapeutic drugs and is currently being tested in clinical trials. However, both intrinsic and acquired resistance of human cancer cells to TRAIL-induced apoptosis poses a huge problem in establishing clinically efficient TRAIL therapies.

Ald-Ph-amido-PEG11-NH-Boc is a non-cleavable 11-unit polyethylene glycol (PEG) linker employed in the synthesis of antibody-drug conjugates (ADCs).

Ald-Ph-amido-PEG11-C2-NH2 is an 11-unit polyethylene glycol (PEG) linker that is non-cleavable. It is specifically designed for use in the synthesis of antibody-drug conjugates (ADCs).

LysoPalloT-NH-amide-C3-ph-m-O-C11 是一种GPR174激动剂，其EC50为34 nM。

VS-II-173 is a novel potent Pim1 and Pim3 inhibitor, selectively inducing AML cell death.

Azodicarbonamide是一个能通过针对nucleocapsid CCHC domains来抑制HIV-1及多种逆转录病毒的核衣壳抑制剂。在标准细胞抗病毒测试中，该化合物能够抑制HIV-1RF引起的CEM-SS细胞病变，其EC50值为38 µM。

AKBA (3-O-Acetyl-11-keto-beta-boswellic acid) 是一种从乳香中分离的天然成分，是新颖的 Nrf2 的活化剂。

ICAAc is a solvatochromic fluorescent pH probe.1 As the polarity of the solvent increases, the emission wavelength of ICAAc increases. It displays excitation/emission maxima of 466/553, 431/515, and 418/503 nm in water, dioxane, and hexane, respectively. The absorption maximum of ICAAc decreases with increasing pH. It displays absorption/emission maxima of 470/554 and 428/553 nm at pH 3 and 11, respectively, in aqueous Britton-Robinson buffer, and the fluorescence intensity increases as pH decreases. ICAAc can be used for live cell applications. |1. Nagy, M., Racz, D., Nagy, Z.L., et al. Amino-isocyanoacridines: Novel, tunable solvatochromic fluorophores as phystiological pH probes. Sci. Rep. 9, 8250 (2019).

monoMICAAc is a solvatochromic fluorescent pH probe.1 As the polarity of the solvent increases, the emission wavelength of monoMICAAc increases. It displays excitation emission maxima of 425 491, 437 515, and 472 554 nm in hexane, dioxane, and water, respectively. The absorption maximum of monoMICAAc decreases with increasing pH. It displays absorbance emission maxima of 475 553 and 446 553 nm at pH 3 and 11, respectively, in aqueous Britton-Robinson buffer, and the fluorescence intensity increases as pH decreases. monoMICAAc can be used for live cell fluorescent applications. |1. Nagy, M., Racz, D., Nagy, Z.L., et al. Amino-isocyanoacridines: Novel, tunable solvatochromic fluorophores as phystiological pH probes. Sci. Rep. 9, 8250 (2019).

CAY10761 is an inhibitor of ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1; IC50s = 467 and 429 μM for the human and snake venom enzymes, respectively).1,2 It also inhibits mushroom tyrosinase (Ki = 1.9 μM) and urease from jack bean, P. mirabilis, and B. pasteurii (IC50s = 0.093, <0.125, and 0.089 mM, respectively, at pH 8.2).3,4 |1. Khan, K.M., Fatima, N., Rasheed, M., et al. 1,3,4-Oxadiazole-2(3H)-thione and its analogues: A new class of non-competitive nucleotide pyrophosphatases phosphodiesterases 1 inhibitors. Bioorg. Med. Chem. 17(22), 7816-7822 (2009).|2. Onyedibe, K.I., Wang, M., and Sintim, H.O. ENPP1, an old enzyme with new functions, and small molecule inhibitors - A STING in the tale of ENPP1. Molecules 24(22), E4192 (2019).|3. Ghani, U., and Ullah, N. New potent inhibitors of tyrosinase: Novel clues to binding of 1,3,4-thiadiazole-2(3H)-thiones, 1,3,4-oxadiazole-2(3H)-thiones, 4-amino-1,2,4-triazole-5(4H)-thiones, and substituted hydrazides to the dicopper active site. Bioorg. Med. Chem. 18(11), 4042-4048 (2010).|4. Amtul, Z., Rasheed, M., Choudhary, M.I., et al. Kinetics of novel competitive inhibitors of urease enzymes by a focused library of oxadiazoles thiadiazoles and triazoles. Biochem. Biophys. Res. Commun. 319(3), 1053-1063 (2004).

TRITC-dextran MW 500000 (Tetramethyl rhodamine isothiocyanate glucan, MW 500000) 是一种分子量为 500 kD 的荧光染料，其激发波长为 555 nm。由于在广泛的 pH 范围（pH 2–11）下保持稳定并且具有抗光漂白的特性，TRITC-dextran MW 500000 常用于药物输送。

TRITC-dextran MW 20000 是一种分子量为 20 kD 的荧光染料，其激发波长为 555 nm。TRITC-dextran MW 20000 可以穿透血管，用于标记血浆以实现脉管系统的可视化。由于 TRITC 在宽 pH 范围（pH 2–11）内稳定且具有抗光漂白特性，TRITC-dextran MW 20000 常用于药物输送。

TRITC-dextran MW 70000 是一种分子量为 70 kD 的荧光染料，其激发波长为 555 nm。由于 TRITC 在 pH 2–11 的范围内具有稳定性并且抗光漂白，因此 TRITC-dextran MW 70000 常用于药物输送。

TRITC-dextran MW 40000 是一种分子量为 40 kD 的荧光染料，激发波长为 555 nm，具有血管穿透性，能够标记血浆以可视化脉管系统。同时，TRITC-dextran MW 40000 可用于药物输送，这得益于TRITC 在广泛的 pH 范围（即 pH 2–11）内保持稳定性，并具抗光漂白特性。

TRITC-dextran MW 150000 是一种分子量为150 kD的荧光染料，激发波长为555 nm。由于其在 pH 2–11 的广泛范围内稳定且具有抗光漂白性，TRITC-dextran MW 150000 被应用于药物输送。

TRITC-dextran MW 2000000是一种分子量为 2000 kD 的荧光染料。其激发波长为 555 nm。由于 TRITC 在 pH 2–11 的广泛范围内保持稳定并具有抗光漂白性，因此 TRITC-dextran MW 2000000 常用于药物输送。

TRITC-dextran MW 4000 是一种分子量为 4 kD 的荧光染料，其激发波长为 555 nm。该化合物具有血管穿透性，可用于标记血浆以实现脉管系统的可视化。此外，TRITC-dextran MW 4000 在药物输送中具有应用价值，因为 TRITC 在 pH 2–11 的范围内具有稳定性，且抗光漂白性良好。