Adenosine receptor inhibitor 1 is a highly potent and selective antagonist of adenosine receptor (AR). It exhibits exceptional affinity for A1 AR, A2A AR, A2B AR, and A3 AR, with respective Ki values of >1000, 68.5, >1000, >1000 nM. This compound demonstrates notable antinociceptive, anti-inflammatory, and peripheral analgesic properties. Therefore, Adenosine receptor inhibitor 1 holds great promise for investigating cancer and neurodegenerative diseases [1].
Orexin A-13C18,15N3(human, rat, mouse) ((Hypocretin-1-13C18,15N3(human, rat, mouse)) TFA 是通过13C 和13N 标记的Orexin A (human, rat, mouse)。Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)) 是由33个氨基酸组成的兴奋性神经肽,参与多种中枢和外周过程,能通过结合并激活G蛋白偶联受体Orexin-1受体 (OX1R) 和 Orexin-2受体 (OX2R) 发挥调节摄食行为的重要作用,这种分子在抗伤害和抗痛觉过敏方面表现出效能。