ornithine aminotransferase

L-Ornithine ((S)-2,5-Diaminopentanoic acid) 是一种非蛋白源性氨基酸。L-Ornithine 主要用于尿素循环，清除体内多余的氮。L-Ornithine 具有肾脏保护作用。L-Ornithine 具有抗疲劳作用。

L-Canaline, a nonprotein amino acid found in many leguminous plants, exhibits potent anticancer and antiproliferative effects. It effectively inhibits the growth of the malaria parasite Plasmodium falciparum with an IC50 of 297 nM. Additionally, L-Canaline acts as a cytotoxic metabolite produced from L-canavanine through arginase catalysis and serves as a potent and irreversible inhibitor of ornithine aminotransferase.

hOAT-IN-1 (compound 5) 是一种针对人鸟氨酸转氨酶 (hOAT) 的机制性抑制剂。它作为时间依赖性抑制剂，与 hOAT 形成紧密结合的 PLP 抑制剂加合物，从而占据 hOAT 的活性位点。hOAT-IN-1 可用于肝细胞癌的研究。

5-Fluoromethylornithine dihydrochloride (5-FMOrn dihydrochloride) 是一种选择性 L-Ornithine:2-oxoacid aminotransferase (OAT) 抑制剂，也是 OAT 的特异性灭活剂，可用于研究代谢疾病和神经系统疾病。