oligomycin

Oligomycin 是一种由链霉菌 (Streptomyces) 产生的大环内酯类抗生素。Oligomycin 常用于研究线粒体功能和细胞能量代谢，具有抗真菌和抗肿瘤活性。

Oligomycin E is a minor metabolite of the oligomycin complex produced by several species of Streptomyces. It exhibits relatively weak antifungal activity compared to other oligomycins, yet is active against Gram-positive bacteria and demonstrates strong antitumor activity against HeLa cells (IC50 = 14 ng ml).

Oligomycin B is an antibiotic isolated from marine Streptomyces, is an eukaryotic ATP synthase inhibitor, induces apoptosis.

Oligomycin C is an antifungal agent isolated from Streptomyces strain.

Oligomycin A (MCH 32) 属于天然产物，是一种线粒体 F0F1-ATPase 抑制剂 (Ki=1 μM)。Oligomycin A 可以抑制线粒体氧化磷酸化，诱导细胞凋亡。Oligomycin A 具有抗真菌活性。

Rutamycin is a macrolide antibiotic of the oligomycin group obtained from Streptomyces rutgersensis. It inhibits various ATPases and uncouples oxidative phosphorylation from electron transport.

44-Homooligomycin A 是一种抗癌抗生素。该化合物对曲霉菌、青霉菌和镰刀菌等真菌有效，但对酵母菌和细菌无效。44-Homooligomycin A 在体内对结肠 26 显示出中等程度的抗肿瘤活性。

44-Homooligomycin B 是一种具有抗肿瘤特性的抗生素。它对曲霉菌、青霉菌和镰刀菌等真菌表现出活性，但对酵母菌和细菌则无效。在体内研究中，44-Homooligomycin B 对结肠 26 展示出中等水平的抗肿瘤活性。