nhe3-in-1

NHE3-IN-1 是钠 质子交换剂 3 (NHE-3) 的抑制剂。

NHE3-IN-2 是Na+ H+交换体 3(NHE3)的抑制剂 。

NHE3-IN-3 (Compound 1) is a potent inhibitor of the isoform 3 of the Na+ H+ exchanger (NHE3). It exhibits pIC50 values of 6.2 and 6.6 against human and rat NHE3, respectively. Furthermore, NHE3-IN-3 showcases exceptional oral bioavailability of 98% in Sprague–Dawley rats [1].