nfps

NFPS exerts neuroprotection via glyR alpha1 subunit in the rat model of transient focal cerebral ischaemia and reperfusion. NFPS is a selective and non-competitive glycine transporter-1 (GlyT1) inhibitor (IC50s: 2.8 nM and 9.8 nM for hGlyT1 and rGlyT1, respectively).

ALX-5407 ((R)-NFPS) 是一种选择性且具口服活性的甘氨酸转运体GlyT1的抑制剂，IC50为3 nM。ALX-5407 可用于研究N-methyl-D天冬氨酸受体的功能及其与精神分裂症的关系。