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nanatinostat

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  • 抑制剂&激动剂
    4
    TargetMol | Inhibitors_Agonists
  • Nanatinostat
    CHR-3996
    T162701256448-47-1
    Nanatinostat is an effective and class I selective inhibitor of histone deacetylase (IC50: 8 nM).
    • ¥ 2520
    In stock
    规格
    数量
  • TLR7/8 agonist 1
    TLR7 8 激动剂 1
    T711081258457-59-8
    TLR7 8 agonist 1是一种 toll 样受体 TLR7 TLR8 激动剂,具有抗癌抗病毒活性,可用于研究与免疫相关的疾病。
    • ¥ 428
    In stock
    规格
    数量
  • (Rac)-Nanatinostat
    (Rac)-Nanatinostat, (Rac)-CHR-3996
    T205112914937-68-1
    (Rac)-Nanatinostat ((Rac)-CHR-3996, example 44) 是一种高效的HDAC抑制剂,IC50低于330 nM。它表现出抗癌特性,有效抑制HeLa、U937和HUT细胞的生长。
    • 待询
    10-14周
    规格
    数量
  • Nanatinostat TFA
    T711101256448-48-2
    Nanatinostat, also known as Tractinostat, CHR-3996 and VRx-3996, is an orally bioavailable, second-generation hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. HDAC inhibitor CHR-3996 inhibits HDAC, resulting in an accumulation of highly acetylated histones, the induction of chromatin remodeling, and the selective transcription of tumor suppressor genes; these events may result in the inhibition of tumor cell division and the induction of tumor cell apoptosis. This agent may upregulate HSP70 and downregulate anti-apoptotic Bcl-2 proteins more substantially than some first-generation HDAC inhibitors. HDACs, upregulated in many tumor cell types, are a family of metalloenzymes responsible for the deacetylation of chromatin histone proteins.
    • ¥ 10600
    6-8周
    规格
    数量