nadph oxidase 4 (nox4)

Fulvene-5 is a chemical compound that exhibits antitumor activity. It functions as a potent inhibitor of NADPH oxidase 4 (NOX4) and possesses antioxidant properties. Additionally, Fulvene-5 acts as a reactive oxygen species (ROS) modifying agent and a powerful radioprotector.

GLX351322 抑制 NADPH 氧化酶 4 (Nox4) 。在 NOX4 过表达的细胞中，抑制过氧化氢的产生，IC50值为 5 μM。

NOX4-IN-1 (Compound 14m) 是一种NADPH氧化酶4（NOX4）的抑制剂，能够抑制ROS的产生。它可以抑制TGF-β1 Smad信号通路，减少与纤维化相关的蛋白表达，并能抑制NRK-49F细胞的迁移。

GK-136901 is a first-in-class, potent, and orally bioavailable NADPH oxidase isoform 4 (Nox4) inhibitor.