mchr1 antagonist 1

MCHR1 antagonist 1 is a selective antagonist of melanin-concentrating hormone-1 (MCH1) receptor (Kb: 1 nM, Ki: 4 nM at human MCH1).

MCHR1 antagonist 2 是有效的黑色素聚集激素受体 1 拮抗剂，IC50为 65 nM。它也抑制hERG，在IMR-32 细胞中的IC50为 4.0 nM。

MCHR1 antagonist 3, a potent antagonist of the melanin-concentrating hormone receptor-1 (MCHR1), is employed for the regulation of energy metabolism.

MCHR1antagonist 4 (Compound 2m) 作为一种穿透血脑屏障的MCHR1拮抗剂,其对hMCHR1和rMCHR1的 Ki值分别是 0.74 nM 和 0.76 nM.此外,该化合物也被认为具已有有效的抗肥胖作用.

SNAP 94847 hydrochloride 是一种选择性黑色素浓缩激素受体1 拮抗剂，Ki 为 2.2 nM，具有抗抑郁样活性。它是 MCH 诱发的肌醇磷酸形成的高亲和力拮抗剂 ，pA2为 7.81。

AZD1979是一种高效的MCHR1(Melanin-concentrating hormone receptor 1)拮抗剂,IC50=12 nM,具有改善的中枢神经系统（CNS）暴露性，改善胰岛素敏感性的稳态模型评估指数，可用于治疗肥胖。

BMS-819881 is a melaninconcentrating hormone receptor 1 (MCHR1) antagonist, which binds rat MCHR1 with a Ki of 7 nM and it also is selective and potent for CYP3A4 activity with an EC50 of 13 μM.

NGD-4715 is a selective and orally active antagonist of melanin-concentrating hormone receptor 1.

T-226296 is a antagonist of melanin concentrating hormone receptor 1 (MCHR1).

ATC0065 dihydrochloride is a novel nonpeptidic and potent melanin-concentrating hormone receptor 1 (MCHR1) selective antagonist.