idr1

IDR-1 is an antimicrobial peptide with activity against both Gram-positive and Gram-negative bacteria. This compound modulates innate immunity to counter infections while avoiding evident toxicities. Additionally, IDR-1 exhibits anti-inflammatory and anti-infective properties, increases the levels of monocyte chemokines, and reduces the release of pro-inflammatory cytokines.

IDR 1002是一种先天性防御调节肽。在小鼠的鼻窦炎感染和细菌性急性肺部感染模型中减少细菌负荷和炎症反应。它抑制LPS诱导的NF-κB和COX-2，促进p38、ERK1/2、MSK1和CREB的磷酸化/激活。

IDR-1018 acetate 是一个先天防御调节剂偶联物，其对MRSA USA300 LAC、MRSA SAP 0017和S. epidermidis ATCC14990的最小抑制浓度（MIC）为16 μg/mL。IDR-1018 被用于合成V-IDR1018（万古霉素-先天防御调节剂偶联物）。