hoe-140

Icatibant is a selective and specific antagonist of the bradykinin B2 receptor (IC50 and Ki: 1.07 nM and 0.798 nM respectively).

Icatibant acetate 是一种特异性缓激肽 B2 受体拮抗剂，其 IC50=1.07 nM，Ki=0.798 nM。

Hoe 140 is an effective antagonist of B1 bradykinin.

[Des-Arg10]-HOE 140 是一种有效的 B1 缓激肽受体拮抗剂，具备生物活性。

Peptide antagonist of the B2 bradykinin receptor (pKi = 10.3); conformationally constrained cyclized analog of HOE 140. Blocks hypotension and bronchoconstriction in vivo. Displays selectivity for B2 over 29 other receptors and ion channels (pIC50 < 5.5).