herpesviruses

Idoxuridine (Dendrid) 是一种抑制病毒 DNA 合成的脱氧尿苷类似物，用作抗病毒剂。

Adefovir 是一种单磷酸腺苷类似物抗病毒剂，在细胞内转化为 Adefovir diphosphate 后可抑制HBVDNA 聚合酶。它在 HepG2.2.15 细胞系中对HBV 的IC50为 0.7 μM。它对多种病毒(包括HBV 和疱疹病毒)具有良好的抗病毒活性。

Eprociclovir (A-5021) 是一种新型阿昔洛韦类似物，是 EHV1 复制的强效抑制剂，可能用于治疗和 或预防该病毒感染。Eprociclovir 对大多数人类疱疹病毒都有很强的抗疱疹活性。

Foscarnet sodium (Phosphonoformate) 是一种病毒 DNA 聚合酶活性抑制剂，可逆地抑制病毒复制。它是一种用于治疗巨细胞病毒性视网膜炎的抗病毒剂。

1,4-Dihydroxynaphthalene 一种有效的 HSV-1蛋白酶抑制剂，对HCMV蛋白酶有抑制作用，可用于研究疱疹病毒。

Brincidofovir (HDP-CDV) 是 Cidofovir 的一种具有口服活性的亲脂性形式的前体药物，是一种口服长效的抗病毒药物，有广泛的抗 DNA 病毒活性。

Lobucavir (BMS-180194; SQ 34514)为一种抗病毒核苷类似物，其具备广谱活性，效力涵盖HBV、HIV AIDS以及各类型疱疹病毒（α、β、γ），包括CMV、单纯疱疹病毒、水痘带状疱疹病毒及Epstein-Barr病毒。

CMV-423 作为一种抗病毒剂，展示了对 β-疱疹病毒类中的人类巨细胞病毒 (HCMV)、人类疱疹病毒 6 型 (HHV-6) 以及 7 型 (HHV-7) 的有效体外活性。该化合物在抗病毒研究领域中具有应用潜力。

Eprociclovir dihydrate is a new acyclovir analogue and a potent inhibitor of EHV1 replication and may have potential for the treatment and or prophylaxis of infections with this virus. Eprociclovir possess potent anti-herpetic activity against most human herpesviruses. A-5021 proved to be about 15-fold more potent than acyclovir in inhibiting viral replication. Eprociclovir inhibits murine herpetic keratitis. A-5021 eyedrops, which are easily applied onto the affected cornea, ameliorated clinical scores and suppressed virus growth. Eprociclovir is a promising alternative treatment of herpetic keratitis.

Eprociclovir Na is the salt form of Eprociclovir, also known as A-5021, a new acyclovir analogue and a potent inhibitor of EHV1 replication and may have potential for the treatment and or prophylaxis of infections with this virus. Eprociclovir possess potent anti-herpetic activity against most human herpesviruses. A-5021 proved to be about 15-fold more potent than acyclovir in inhibiting viral replication. Eprociclovir inhibits murine herpetic keratitis. A-5021 eyedrops, which are easily applied onto the affected cornea, ameliorated clinical scores and suppressed virus growth. Eprociclovir is a promising alternative treatment of herpetic keratitis.

Eprociclovir potassium is a new acyclovir analogue and a potent inhibitor of EHV1 replication and may have potential for the treatment and or prophylaxis of infections with this virus. Eprociclovir possess potent anti-herpetic activity against most human herpesviruses. A-5021 proved to be about 15-fold more potent than acyclovir in inhibiting viral replication. Eprociclovir inhibits murine herpetic keratitis. A-5021 eyedrops, which are easily applied onto the affected cornea, ameliorated clinical scores and suppressed virus growth. Eprociclovir is a promising alternative treatment of herpetic keratitis.

Isoxanthohumol 是一种从啤酒花和啤酒中提取的一种前黄酮类化合物，对几种人类癌细胞株具有抗增殖活性。Isoxanthohumol对肿瘤细胞肺转移灶的转移或侵袭有抑制作用。Isoxanthohumol具有抗病毒活性，对疱疹病毒（HSV1和HSV2）和牛病毒性腹泻病毒（BVDV）具有抑制作用。

DNA polymerase-IN-5 (compound 42) 是一种有效对抗 CMV 和 VZV 的广谱抗疱疹病毒化合物,其中对 CMV 的 IC50 为 6.6 μM,对 VZV 的 IC50 为 4.8 μM.