falciparum strain

Oxysanguinarine (Hydroxysanguinarine) 是一种来自Meconopsis simplicifolia 的小檗生物碱，具有抗疟和抗血小板聚集活性，对登革热病毒具有潜在的抑制作用。

LysRs-IN-2 是一种赖氨酸 tRNA 合成酶 (KRS) 抑制剂，有抗寄生虫感染的作用，抑制恶性疟原虫 KRS (PfKRS) 和小隐孢子虫 KRS (CpKRS) ，可用于研究疟疾感染。

MMV665916 是一种喹唑啉二酮衍生物，是一种抗疟药。MMV665916 对恶性疟原虫 FcB1 菌株具有显著的抗疟原虫生长抑制活性，EC50值为 0.4 μM，并呈现出高选择性指数 (SI>250)。

MMV008138 inhibits the growth of P. falciparum Dd2 strain (IC50 of 250 nM).

Compound 31 (Antiproliferative agent-56) 具有针对恶性疟原虫Pf3D7的抗疟活性，表明能显著抑制Plasmodium falciparum 3D7。其IC50值分别为 >12.5 μM (48h) 和 0.03 μM (98h)，显示出缓慢的作用效果。

Villalstonine，一种具抗癌、抗疟以及抗阿米巴原虫效果的双吲哚生物碱，对抗多药耐药性恶性疟原虫K1株表现出显著效能，其IC50为0.27 μM。

Cordysinin C D (compound 9) 是一种潜在的抗疟原虫化合物，对恶性疟原虫 3D7 株系具有有效的抑制作用。

Antimalarial agent 47 (compound F14) 是一种用于抗疟原虫的化合物，其对恶性疟原虫 W2 菌株的IC50值为235 nM。

Dehydrocorydaline nitrate 是生物碱。Dehydrocorydaline 调节 Bax，Bcl-2蛋白表达，激活 caspase-7，caspase-8，并使 PARP 失活。它能增强 p38 MAPK 活化，具有抗炎、抗癌、抗疟疾等功效。

6-Prenylindole is a bacterial metabolite that has been found in Streptomyces and has antifungal and antimalarial properties.1 It is active against A. brassicicola strain TP-F0423 and F. oxysporum f. sp. tulipae TU-4-2 (15 and 30 μg disc in the paper disc assay), and also drug-resistant P. falciparum strain K1 (IC50 = 21 μg ml).2 |1. Sasaki, T., Igarashi, Y., Ogawa, M., et al. Identification of 6-prenylindole as an antifungal metabolite of Streptomyces sp. TP-A0595 and synthesis and bioactivity of 6-substituted indoles. J. Antibiot. (Tokyo) 55(11), 1009-1012 (2002).|2. Nkunya, M.H., Makangara, J.J., and Jonker, S.A. Prenylindoles from Tanzanian Monodora and Isolona species. Nat. Prod. Res. 18(3), 253-258 (2004).

Violacein is a bacterial metabolite originally isolated from C. violaceum that has antibacterial and antiprotozoal activities.[1] [2] It is produced by C. violaceum as a purple pigment in response to N-hexanoyl homoserine lactone , a property that has been modified to create a strain of C. violaceum used in detecting quorum-sensing molecules.[3] Violacein is active against Gram-positive bacteria, including B. subtilis and S. aureus (MICs = 0.8 and 1.6 µM, respectively). It is also active against P. falciparum, including chloroquine-susceptible and -resistant strains (IC50s = 0.85 and 0.63 µM, respectively).[2] It reduces parasitemia in a mouse model of nonlethal P. chabaudi chabaudi infection when administered at a dose of 7.5 mg/kg and increases survival in a mouse model of lethal P. chabaudi chabaudi infection. Violacein permeabilizes the cytoplasmic membrane of bacterial cells but does not affect the cell wall.[1]

Butyrolactone V is a fungal metabolite that has been found in A. terreus and has antiprotozoal, antioxidant, and anticancer activities.1,2,3 It is active against the P. falciparum strain K1 (IC50 = 7.9 μg ml) and L. amazonensis promastigotes (IC50 = 23.7 μM).2,1 Butyrolactone V (227 and 454.1 μM) is also active against adult S. mansoni worms.1 It scavenges 2,2-diphenyl-1-picrylhydrazyl and ABTS radicals with IC50 values of 20.7 and 3.7 μM, respectively, in cell-free assays.3 Butyrolactone V also inhibits proliferation of MDA-MB-231 and MCF-7 breast cancer cells (IC50s = 22.2 and 31.9 μM, respectively).1

RYL-552S 是一种可杀死恶性疟原虫 Plasmodium falciparum 的耐药菌株，其可在体外有效杀灭无性血内阶段的寄生虫。

Dehatrine is from an Indonesian medical plant Beilschmiedia madang; a bisbibenzylisoquinoline alkaloid; inhibits growth of cultured Plasmodium falciparum K1 strain.

Antimalarial agent 20 是一种抗疟剂，在 NF54 蛋白测定中对P. falciparumNF54 寄生菌株的IC50为 0.6 nM。

Z-Antiepilepsirine 是一种酰胺生物碱，存在于 Piper capense L.f 中。Z-Antiepilepsirine 显示抗疟原虫活性，对 PlasmodiumfalciparumW2 菌株的 IC50值为 27 µM。

MMV009085是一种针对恶性疟原虫己糖转运体PfHT1的特异性抑制剂，具有潜在的抗疟效果。它同时抑制人葡萄糖转运蛋白，强效抑制葡萄糖吸收（IC50：2.6 μM）及恶性疟原虫3D7株的生长（EC50：1.23±0.04 μM）。

Antimalarial agent 24（Compound 7）是一种抗疟化合物，具有显著的体外（in vitro）活性。针对P. falciparum W2菌株，其IC50值为0.81 μM。同时，Antimalarial agent 24展现在HepG2细胞上的CC50值高于200 μM，表明其对宿主细胞具有较高安全性。

Antileishmanial agent-21 (compound 4e)，是靶向利什曼原虫蝶啶还原酶1 (Lm-PTR1) 的抗利什曼虫试剂。该化合物通过抗叶酸机制发挥作用，且其抗利什曼活性能被叶酸和亚叶酸逆转。Antileishmanial agent-21 还能抑制对 Chloroquine 抗性的恶性疟原虫菌株 (RKL9)，IC50 范围为0.0198-0.096 μM。

Antimalarial agent 33 (compound 5g) 显示针对红细胞期和肝期疟原虫的抗活性，特别是对 K1 恶性疟原虫株，其EC50为1.1 μM。Antimalarial agent 33 还展示出提升的微粒体稳定性（T1 2=29分钟），并且对原代肝细胞未表现出明显的细胞毒效应。

N-didesmethyl Loperamide是loperamide的一个活性代谢产物，属于周围μ1-阿片受体激动剂。它能抑制孤立的豚鼠肠膜丛中由电刺激引起的收缩(IC50 = 370 nM)。N-didesmethyl Loperamide还能增强对氯喹产生抗药性的P. falciparum菌株对氯喹的敏感性(EC50 = 482 nM)，同时在A-10血管平滑肌细胞中未引起毒性(IC50 = >10,000 nM)。

Phosphodiesterase-IN-1 (Compound 7) 为一种针对磷酸二酯酶（PDE）的抑制剂，表现出对疟原虫的活性。该化合物在抑制P. falciparum（strain 3D7）的增殖方面表现有效，其IC50为0.64 μM。

Antimalarial agent 38（Compound 1）作为一种有效的抗疟药物，能够抑制多种Plasmodium falciparum 株，包括氯喹敏感的 Thai 株以及氯喹耐药的 FcB1 株和 K1 株，其 IC50 值分别为 0.5 μM, 13 μM, 1 μM 和 13 μM。此外，Antimalarial agent 38 对哺乳动物细胞 MCR58 显示出低细胞毒性（IC50 > 140 μM），并能有效提升因Plasmodium yoelii nigeriensis感染小鼠的生存率。

Homogentisic acid (2,5-dihydroxyphenylacetic acid) 是一种尿液和血清代谢物中的特定代谢物，可用于尿黑酸尿症的诊断。