falciparum strain

Oxysanguinarine (Hydroxysanguinarine) 是一种来自Meconopsis simplicifolia 的小檗生物碱，具有抗疟和抗血小板聚集活性，对登革热病毒具有潜在的抑制作用。

Villalstonine，一种具抗癌、抗疟以及抗阿米巴原虫效果的双吲哚生物碱，对抗多药耐药性恶性疟原虫K1株表现出显著效能，其IC50为0.27 μM。

Dehydrocorydaline nitrate 是生物碱。Dehydrocorydaline 调节 Bax，Bcl-2蛋白表达，激活 caspase-7，caspase-8，并使 PARP 失活。它能增强 p38 MAPK 活化，具有抗炎、抗癌、抗疟疾等功效。

Violacein is a bacterial metabolite originally isolated from C. violaceum that has antibacterial and antiprotozoal activities.[1] [2] It is produced by C. violaceum as a purple pigment in response to N-hexanoyl homoserine lactone , a property that has been modified to create a strain of C. violaceum used in detecting quorum-sensing molecules.[3] Violacein is active against Gram-positive bacteria, including B. subtilis and S. aureus (MICs = 0.8 and 1.6 µM, respectively). It is also active against P. falciparum, including chloroquine-susceptible and -resistant strains (IC50s = 0.85 and 0.63 µM, respectively).[2] It reduces parasitemia in a mouse model of nonlethal P. chabaudi chabaudi infection when administered at a dose of 7.5 mg/kg and increases survival in a mouse model of lethal P. chabaudi chabaudi infection. Violacein permeabilizes the cytoplasmic membrane of bacterial cells but does not affect the cell wall.[1]

Butyrolactone V is a fungal metabolite that has been found in A. terreus and has antiprotozoal, antioxidant, and anticancer activities.1,2,3 It is active against the P. falciparum strain K1 (IC50 = 7.9 μg/ml) and L. amazonensis promastigotes (IC50 = 23.7 μM).2,1 Butyrolactone V (227 and 454.1 μM) is also active against adult S. mansoni worms.1 It scavenges 2,2-diphenyl-1-picrylhydrazyl and ABTS radicals with IC50 values of 20.7 and 3.7 μM, respectively, in cell-free assays.3 Butyrolactone V also inhibits proliferation of MDA-MB-231 and MCF-7 breast cancer cells (IC50s = 22.2 and 31.9 μM, respectively).1

Z-Antiepilepsirine 是一种酰胺生物碱，存在于 Piper capense L.f 中。Z-Antiepilepsirine 显示抗疟原虫活性，对 PlasmodiumfalciparumW2 菌株的 IC50值为 27 µM。

Homogentisic acid (2,5-dihydroxyphenylacetic acid) 是一种尿液和血清代谢物中的特定代谢物，可用于尿黑酸尿症的诊断。

Batzelladine F 是Plasmodium falciparum的有效抑制剂 (IC503D7= 0.13 μM)，对HepG2 细胞具有中等细胞毒性 (CC50=10.6 μM)，并展现出抗疟作用，有潜力用于抗疟药物研究。

Phomoxanthone A 是一种可从Phomopsis中提取的黄酮二聚体。它对恶性疟原虫Plasmodium falciparum (K1，耐多药菌株) 的IC50为0.11 µg/mL，对结核分枝杆菌Mycobacterium tuberculosis (H37Ra 菌株) 的MIC为0.50 µg/mL，表现出抗疟和抗结核活性。此外，Phomoxanthone A 在KB、BC-1 和 Vero 细胞中具有细胞毒性，其IC50分别是0.99、0.51 和 1.4 µg/mL。

Dehydrocorydaline hydroxyl (13-Methylpalmatine) 是一种生物碱。它调节Bax和Bcl-2蛋白的表达；激活caspase-7和caspase-8，并使PARP失活。Dehydrocorydaline hydroxyl 促进p38 MAPK激活，具有抗炎和抗癌作用。此化合物还具有强大的抗疟疾效果，并且细胞毒性低 (细胞生存力> 90％)，对P. falciparum 3D7 strain的IC50为38 nM。

Canophyllal shows antiplasmodial activity against the W2 strain of Plasmodium falciparum which is resistant to chloroquine and other antimalarial drugs.

Garcinone E is active constituents in the anticomplement assay used. Garcinone E exhibits potent activity in vitro against Plasmodium falciparum chloroquine-resistant strain W2, with IC50 values below 3 µM. It has potent cytotoxic effect on all hepatocellular carcinomas cell lines as well as on the other gastric and lung cancer cell lines included in the screen, may be potentially useful for the treatment of certain types of cancer.

Longistylin A and longistylin C show some cytotoxic effects, with IC(50) values of 0.7-14.7 microM against the range of cancer cell lines. Longistylin A and longistylin C, and betulinic acid show a moderately high in vitro activity against the chloroquine

Oplopanone exhibits noteworthy anti-plasmodial activity against Plasmodium falciparum strain.