erd-308

ERD-308 induces >95% of ER degradation at concentrations as low as 5 nM in both cell lines (DC50 (concentration causing 50% of protein degradation) of 0.17 nM and 0.43 nM in MCF-7 and T47D ER+ cells, respectively).ERD-308 is a highly potent PROTAC degrade

(S,R,S)-AHPC-Me-amide-C-O-C5-Br 含有用于招募 E3 泛素连接酶的 VHL 配体及 linker，可以用于合成多种 PROTAC 分子，包括 ERD-308。

tert-Butyl 2-((5-bromopentyl)oxy)acetate 是一种PROTAC连接子 (PROTAC linker)，用于合成ERD-308。