e3 ligase ligand-linker conjugates 7

(S,R,S)-AHPC-PEG4-NH2 (VHL Ligand-Linker Conjugates 4) 是一种合成的 E3 连接酶配体-接头偶联物，包含基于 (S,R,S)-AHPC 的 VHL 配体和 4 单元 PEG 接头。

(S, R, S)-AHPC-PEG4-NH2 hydrochloride is a chemically synthesized conjugate consisting of an E3 ligase ligand-linker, incorporating the VHL ligand based on (S, R, S)-AHPC, and a 4-unit PEG linker, which are specifically designed for use in PROTAC technology.

cIAP1 Ligand-Linker Conjugates 7 is a chemical compound that combines an IAP ligand for the E3 ubiquitin ligase with a PROTAC linker. It is utilized in the design of SNIPERs[1].

(S,R,S)-AHPC-PEG2-C4-Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker. (S,R,S)-AHPC-PEG2-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1].

Thalidomide-O-amido-C3-COOH is a synthesized conjugate of an E3 ligase ligand-linker compound that combines a cereblon ligand derived from Thalidomide with a linker commonly employed in PROTAC technology.

(R,S,S)-VH032-Me-N-Boc-7-aminoheptanoic acid 是一种 E3 连接酶配体与连接子的缀合物 (E3LigaseLigand-Linker Conjugates)，由 N-Boc-7-aminoheptanoic acid 和特定的 Linker 组成。(R,S,S)-VH032-Me-N-Boc-7-aminoheptanoic acid 可用于合成 dTAGV-1-NEG。

E3 Ligase Ligand-linker Conjugate 7 是由 Thalidomide 和相应的 Linker 缀合而成的 E3 连接酶配体-连接子复合体（E3 Ligase Ligand-Linker Conjugates）。它能作为 Cereblon 配体来募集 CRBN 蛋白，并作为合成完整 PROTACs 分子的关键中间体。