dpc-aj1951

Potent 14 amino acid peptide agonist of the parathyroid hormone (PTH) receptor (EC50 = 26 nM).

DPC-AJ1951 is a peptide agonist of the parathyroid hormone (PTH) PTH-related peptide receptor (PPR; EC50 = 0.15 nM in HEK293 cells expressing human PPR). It induces cAMP production in SAOS-2 and UMR106 cells that endogenously express human and rat PPR, respectively (EC50s = 2.2 and 1.1 nM, respectively). DPC-AJ1915 stimulates osteoclast-mediated bone resorption in fetal rat long-bone explant cultures and increases collagen synthesis and cell proliferation in neonatal mouse parietal bone explants. In vivo, DPC-AJ1951 normalizes serum calcium levels in thyroidparathyroidectomized rats.

DPC-AJ1951 TFA，是一种含有14个氨基酸的肽类化合物，有效充当甲状旁腺激素(PTH) PTH相关肽受体(PPR)激动剂，在体外及体内骨吸收实验中展现活性。

DPC-AJ1951 acetate 是一种 14 个氨基酸的肽，可作为甲状旁腺激素 (PTH) PTH 相关肽受体 (PPR) 的有效激动剂。在骨吸收的体外和体内测定中表征了它的活性。