dkfzp781e-2378

Expression system: HEK293 Cells
Length: 22-225, Partial
Activity: Not Tested

Expression system: HEK293 Cells
Length: 1-225, Partial
Activity: Not Tested

Expression system: HEK293 Cells
Length: 1-221, Partial
Activity: ELISA

CD84 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.2 kDa and the accession number is F6QA53.

CD84 Protein, Cynomolgus, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 23.6 kDa and the accession number is XP_005541302.1.

Expression system: HEK293 Cells
Length: 22-220, Partial
Activity: Not Tested

Expression system: HEK293 Cells
Length: 22-220, Partial
Activity: Not Tested

CD84, also called SLAMF5, is a member of the CD2 subgroup of the immunoglobulin receptor superfamily. Members of this CD2 subgroup mediate signal transduction through the interaction of its immunoreceptor tyrosine-based switch motifs (ITSM) in the intracellular region and the SH2 domain of adaptor molecules SAP (SLAM-associated protein) and EAT-2 (EWS-activated transcript 2), and accordingly modulate both adaptive and innate immune responses. CD84 expression has been documented on several hematopoietic cell types, including monocytes, macrophages, dendritic cells, B lymphocytes, and platelets. Activation of cell surface CD84 initiates a signaling cascade involving its intra-cytoplasmic tyrosine residues that results in Bcl-2 upregulation, which in turn enhances cell survival. Either immunoneutralization or blockade of CD84 with a CD84 extracellular domain protein fragment induces cell death in vitro and in vivo.