dc-034

DC-034 is a potent downregulator of MYC transcription in cancer cells by a G4-dependent mechanism, thereby selectively inhibiting MYC significantly greater than other G4-driven genes.

NGB-2849 is a selective dopamine D3 receptor antagonist.

GDC-0349 (RG-7603) 是一种ATP 竞争性的选择性mTOR 抑制剂，Ki 值为 3.8 nM。它对 PI3Kα 和其他 266 种激酶的抑制作用是 790 倍，可抑制mTORC1和mTORC2复合体。