chlorhexidine hydrochloride

Chlorhexidine dihydrochloride (NSC-185) 是一种消毒剂和局部抗感染剂，也用作漱口水以防止口腔菌斑。

Chlorhexidine-D8 hydrochloride is intended for use as an internal standard for the quantification of chlorhexidine by GC- or LC-MS. Chlorhexidine is a bis (biguanide)antimicrobial disinfectant and antiseptic agent. It inhibits growth of clinical methicillin-resistant S. aureus (MRSA) isolates (MIC90 = 4 μg/ml). It is also active against canine isolates of MRSA,methicillin-susceptible S. aureus (MSSA),methicillin-resistant S. pseudintermedius (MRSP),and methicillin-susceptible S. pseudintermedius (MSSP; MIC90s = 4,2,2,and 1 mg/L,respectively). Chlorhexidine inhibits growth of E. faecium strains (MICs = 1.2-19.6 μg/ml)and C. albicans (MIC = 5.15 μg/ml). It generates cations that bind to and destabilize the bacterial cell wall to induce death.6 Chlorhexidine also completely inhibits matrix metalloproteinase-2 (MMP-2)and MMP-9 when used at concentrations of 0.0001 and 0.002%,respectively,in a gelatin degradation assay. Formulations containing chlorhexidine have been used in antisept......

Meclocycline is a tetracycline antibiotic with broad antimicrobial activity. Meclocycline inhibits lactate dehydrogenase (LDH) release and cell toxicity induced by expression of htt-N63-148Q, a mutant form of the huntingtin gene, without altering htt-N63-148Q protein levels in PC12 cells.