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chk1 in 3

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  • 抑制剂&激动剂
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    TargetMol | Inhibitors_Agonists
  • CHK1-IN-3
    T107912097252-39-4In house
    CHK1-IN-3 是一种检测点激酶 (CHK1) 抑制剂,IC50 值为 0.4 nM。
    • ¥ 1290
    现货
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    数量
  • CCT241533 dihydrochloride
    CCT 241533 dihydrochloride
    T367041962925-28-5
    Potent Chk2 inhibitor (IC50 = 3 nM). Shows >63-fold selectivity for Chk1 over Chk2 and a panel of 84 other kinases. Inhibits Chk2 activation in response to etoposide-induced DNA damage in HT29 cells. Blocks ionizing radiation-induced apoptosis of mouse thymocytes. Caldwell et al (2011) Structure-based design of potent and selective 2-(quinazolin-2-yl)phenol inhibitors of checkpoint kinase 2. J.Med.Chem. 54 580 PMID:21186793
    • 待估
    35日内发货
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    数量
  • pd-321852
    T68981622856-21-7
    PD-321852 is a small-molecule Chk1 inhibitor, which potentiates gemcitabine-induced clonogenic death in a panel of pancreatic cancer cell lines and evaluated the relationship between endpoints associated with Chk1 inhibition and chemosensitization. Gemcitabine chemosensitization by minimally toxic concentrations of PD-321852 ranged from minimal (<3-fold change in survival) in Panc1 cells to >30-fold in MiaPaCa2 cells. PD-321852 inhibited Chk1 in all cell lines as evidenced by stabilization of Cdc25A; in combination with gemcitabine, a synergistic loss of Chk1 protein was observed in the more sensitized cell lines.
    • ¥ 15000
    8-10周
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    数量