cabazitaxel-d6

Cabazitaxel-D6 is a deuterium labeled cabazitaxel. Cabazitaxel (T2543) is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Cabazitaxel (T2543)binds to and stabilizes tubulin,resulting in the inhibition of microtubule depolymerization and cell division,cell cycle arrest in the G2/M phase,and the inhibition of tumor cell proliferation. Unlike other taxane compounds,this agent is a poor substrate for the membrane-associated,multidrug resistance (MDR),P-glycoprotein (P-gp)efflux pump and may be useful for treating multidrug-resistant tumors. In addition,cabazitaxel penetrates the blood-brain barrier (BBB).

Cabazitaxel-D6 (Standard) 是 Cabazitaxel-D6 的标准品，适用于定量分析、质量控制及生化实验等相关研究。Cabazitaxel-d6 是氘标记的Cabazitaxel。Cabazitaxel是天然的紫杉烷化合物 10-脱乙酰巴卡丁三醇的一种半合成衍生物，具有潜在的抗肿瘤活性。Cabazitaxel与微管结合并使其稳定，从而抑制微管解聚和细胞分裂，使细胞周期停滞在 G2/M 期，并抑制肿瘤细胞的增殖。