aza-1

AZA1 (Rac1 Cdc42-IN-1) 是一种有效的Rac1和Cdc42双重抑制剂。AZA1 诱导前列腺癌细胞凋亡，抑制癌细胞增殖，迁移和侵袭。

Diaza-15-crown-5 能延长 BR 膜中 M 中间体的持续时间。Diaza-15-crown-5 属于冠醚化合物，能够改变 BR 膜的表面电荷，从而影响 BR 分子之间的相互作用和整个膜的稳定性，使 M 态得以更长时间地维持。

AZA197 (AZA-197)是一种选择性 Cdc42抑制剂。在临床前小鼠异种移植模型中，它通过下调 PAK1活性来抑制原发性结肠癌的生长并延长生存期。

Spermine (Neuridine) 作为一个直接的自由基清除剂，具有抗病毒作用，能够保护 DNA 免受自由基的攻击。

Ixabepilone (Azaepothilone B) 是一种可口服的微管抑制剂，能够与微管蛋白结合，促进微管蛋白的聚合和微管的稳定，使细胞停滞在 G2-M 期，诱导细胞凋亡。

(5Alpha)-23-methyl-4-aza-21-norchol-1-ene-3,20-dione is a bioactive chemical.

GS-441524tris-isobutyryl ester is a prodrug form of the antiviral nucleoside analog and remdesivir metabolite GS-441524 .1It reduces the cytopathic effect of respiratory syncytial virus (RSV) in infected HEp-2 cells with an EC50value of 0.26 μM. 1.Mackman, R.L., Hui, H.C., Perron, M., et al.Prodrugs of a 1’-CN-4-aza-7,9-dideazaadenosine C-nucleoside leading to the discovery of remdesivir (GS-5734) as a potent inhibitor of respiratory syncytial virus with efficacy in the african green monkey model of RSVJ. Med. Chem.64(8)5001-5017(2021)

GM 1489 is a broad-spectrum inhibitor of matrix metalloproteinases (MMPs) with Ki values of 0.002, 0.1, 0.5, 0.2, and 20 μM for MMP-1, MMP-8, MMP-2, MMP-9, and MMP-3, respectively. It reduces 5-aza-2'-deoxycytidine-induced increases in MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, and MMP-14 expression as well as cell invasion in AsPC-1, BxPC-3, Hs766T, MiaPaCa2, and PANC-1 cancer cells. Topical administration of GM 1489 (100 μg) inhibits increases in ear thickness and epidermal hyperplasia induced by phorbol 12-myristate 13-acetate and phorbol dibutyrate (PdiBu) in mice.

2-Amino-8-aza-7-deaza-7-iodoguanosine 是一种嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性，靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制 DNA 合成，诱导细胞凋亡 (apoptosis) 等。

5-Aza-xylo-cytidine为嘌呤核苷类似物，拥有针对惰性淋巴系统恶性肿瘤的广泛抗肿瘤活性。其抗癌机制主要通过抑制DNA合成和诱导细胞凋亡(apoptosis)实现。

5-Azacytidine 5′-triphosphate (5-aza-CMP) 为一种胞苷类似物，可抑制 DNA 依赖性 RNA 聚合酶反响中的 [3H]CTP 并入 RNA，而不影响 [3H]UTP 的并入。

5-Aza-4'-thio-2'-deoxycytidine (5-Aza-T-dCyd)为口服有效的DNMT1抑制剂，并具备抗肿瘤能力。此化合物作为含硫脱氧胞苷类似物，展现出对DNA低甲基化的潜在作用。

1-(b-D-Xylofuranosyl)-6-azauracil is a Nucleoside Derivative - Xylo-nucleoside; 6-Aza-uridine.

6-Amino-3-ethynyl-4-methoxy-1-(b-D-ribofuranosyl)-1H- pyrazolo[3,4-d]pyrimidine is a Nucleoside Derivative - 8-Aza-7-deaza-purine nucleoside; 6-Modified purine nucleoside.

6-Amino-3-(furan-2-yl)-4-methoxy-1-(b-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine is a Nucleoside Derivative - 8-Aza-7-deaza-purine nucleoside; 6-Modified purine nucleoside.

3,6-Dibromo-1,5-dihydro-1-(2,3,5-tri-O-benzoyl-b-D-ribofuranosyl)-4H-pyrazolo[3,4-d]pyrimidin-4-one is a Nucleoside Derivative - 7-Deaza-8-aza-purine nucleoside; Halo-nucleoside; Scaffold and Template.