at 202

SR16835 is a NOP receptor agonist, with low-affinity bifunctional activity at the μ opioid receptor.

CHMFL-EGFR-202 是一种有效、不可逆的表皮生长因子受体 (EGFR) 突变型激酶抑制剂， 对耐药突变型 EGFR T790M 和 WT EGFR 激酶作用的 IC50 分别为 5.3 nM 和 8.3 nM。

N-deacetylated BMS-202 是 PD-1 PD-L1 相互作用的抑制剂，具有潜在的抗癌活性，可用于研究癌症。

(Rac)-ABT-202 dihydrochloride 是 ABT-202 的外消旋体。ABT-202 是烟碱乙酰胆碱受体激动剂，可用作镇痛剂。

UP202-56 is an adenosinergic agonist and is an adenosine analog.

DD202-114 作为一种高效与选择性的 GLP1R 激动剂，可以促进 cAMP 的积累，降低血糖水平并减少食物摄入。它在 2 型糖尿病 (T2DM) 及肥胖症的研究中显示出潜在应用价值。

L202，一种具有电离性的阳离子脂质(pKa=6.04)，常被应用于mRNA及脂质纳米颗粒研究领域。

YZ-202是orbofiban的自由酸形式。作为II类GPIIb IIIa拮抗剂，YZ-202在抑制血小板聚集方面与I类拮抗剂（如XV459和DMP802）具有可比的效力，但在改变TF介导的血凝块形成力度方面的潜力较低。这表明尽管具有类似的抗聚集效力，YZ-202在血小板-纤维蛋白血块收缩方面可能存在差异性作用。

G202-0362 is an antiviral agent against Rift Valley fever virus. It acts by blocking virus budding from the trans Golgi.

ABT-202 is a drug developed by Abbott that acts as an agonist for the nerve's nicotinic acetylcholine receptor and has been studied as a painkiller.

Kih 202 have hypoxic cytotoxicity to FM3A cells from C3H mice.

LYG-202是一种具有哌嗪替代的新型类黄酮，在体内和体外都具有抗肿瘤作用。LYG-202 诱导 MCF-7、MDA-MB-231 和 MDA-MB-435 细胞凋亡， 增加了细胞内 ROS 的产生。

Sibofimloc (Antibiotic-202) 是一种肠道限制性的，具有口服活性的 FimH 粘附抑制剂，有抗细菌感染活性，被开发用于治疗炎症性肠病的研究。

Domatinostat tosylate (4SC-202) 是一种 I 型 HDAC 抑制剂，能够抑制 HDAC1、HDAC2和 HDAC3 的活性，IC50值分别为 1.20 μM、1.12 μM 和 0.57 μM。它也抑制组蛋白赖氨酸特异性脱甲基酶1 的活性。

BMS202 hydrochloride (1675203-84-5(free base)) (PD-1 PD-L1 inhibitor 2 hydrochloride) 是一种小分子 PD-1 PD-L1 相互作用抑制剂 (IC50: 18 nM)。生物物理研究表明 BMS202 直接与 PD-L1 结合。 BMS202 的结合促进 PD-L1 二聚化并阻断 PD-L1 PD1 相互作用。

Domatinostat (4SC202) 是一种 I 型 HDAC 抑制剂，能够抑制 HDAC1、HDAC2和 HDAC3 的活性，IC50值分别为 1.20 μM、1.12 μM 和 0.57 μM，同时能够抑制组蛋白赖氨酸特异性脱甲基酶1 的活性。

Phospho-p44 42 MAPK (Erk1 2) (Thr202 Tyr204) (20G11) Rabbit mAb #4376R 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T64608。

ML202作为一种变构激活剂，针对人丙酮酸激酶M2 (hPK-M2)展现出高度特异性，能够影响磷酸烯醇丙酮酸(PEP)结合的协同性，而对二磷酸腺苷(ADP)的结合几乎无影响。

Anti-Enterovirus 71 VP4 Antibody (3E202) 是一种靶向EV71 Enterovirus 71 VP4 的单克隆抗体，是一种 Mouse IgG1 抗体。

Ribosomal protein L3 peptide (202-222) is a peptide with the sequenceH2N-Met-Ser-His-Arg-Lys-Tyr-Glu-Ala-Pro-Arg-His-Gly-His-Leu-Gly-Phe-Leu-Pro-Arg-Lys-Arg-amide, MW=2573.

Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities, including antibacterial, anticancer, antiplatelet, and antioxidant properties.1,2,3,4It is active against Gram-positive (MICs = 5-160 µg ml) and Gram-negative bacteria (MICs = 136-200 µg ml), as well as yeasts (MICs = 10-20 µg ml).1Ajoene is cytotoxic to mouse melanoma cells (IC50= 18 µM), as well as human colon, lung, mammary, and pancreatic cancer cells (IC50s = 7-41 µM).2It reduces tumor growth in a B16 BL6 mouse model of melanoma when administered at a dose of 25 mg kg every other day and decreases the number of lung metastases when administered prior to tumor cell inoculation at doses ranging from 1-25 mg kg. It inhibits ADP- or collagen-induced platelet aggregation in isolated baboon platelets when used at concentrations ranging from 75 to 150 µg ml and in platelet-rich plasma isolated from baboons when administered at a dose of 25 mg kg.3Ajoene (25 mg kg) prevents thrombus formation on damaged arterial walls in heparinized pigs in anin situmodel of thrombogenesis.5It also reduces high-fat diet-induced hepatic steatosis, histopathological markers of liver damage, thiobarbituric acid reactive substances (TBARS) formation, and protein oxidation in a mouse model of non-alcoholic fatty liver disease (NAFLD).4 1.Naganawa, R., Iwata, N., Ishikawa, K., et al.Inhibition of microbial growth by ajoene, a sulfur-containing compound derived from garlicAppl. Environ. Microbiol.62(11)4238-4242(1996) 2.Taylor, P., Noriega, R., Farah, C., et al.Ajoene inhibits both primary tumor growth and metastasis of B16 BL6 melanoma cells in C57BL 6 miceCancer Lett.239(2)298-304(2006) 3.Teranishi, K., Apitz-Castro, R., Robson, S.C., et al.Inhibition of baboon platelet aggregation in vitro and in vivo by the garlic derivative, ajoeneXenotransplantation10(4)374-379(2003) 4.Han, C.Y., Ki, S.H., Kim, Y.W., et al.Ajoene, a stable garlic by-product, inhibits high fat diet-induced hepatic steatosis and oxidative injury through LKB1-dependent AMPK activationAntioxid. Redox Signal.14(2)187-202(2011) 5.Apitz-Castro, R., Badimon, J.J., and Badimon, L.A garlic derivative, ajoene, inhibits platelet deposition on severely damaged vessel wall in an in vivo porcine experimental modelThromb. Res.75(3)243-249(1994)

Psychotridine is an alkaloid that has been found inP. forsterianaand has diverse biological activities.1,2,3It inhibits ADP-, collagen-, or thrombin-induced aggregation of washed isolated human platelets with IC50values of 1.4, 1.4, and 3.9 μM, respectively.1Psychotridine (2.5 or 5 μM) is cytotoxic to HTC rat hepatocellular carcinoma cells.2It reduces paw licking induced by capsaicin in mice when administered at doses of 0.5, 2.5, or 5 mg kg.3 1.Beretz, A., Roth-Georger, A., Corre, G., et al.Polyindolinic alkaloids from Psychotria forsteriana. Potent inhibitors of the aggregation of human plateletsPlanta Med.51(4)300-303(1985) 2.Roth, A., Kuballa, B., Bounthanh, C., et al.Cytotoxic activity of polyindoline alkaloids of Psychotria forsteriana (Rubiaceae) (1)Planta Med.6450-453(1986) 3.Amador, T.A., Verotta, L., Nunes, D.S., et al.Involvement of NMDA receptors in the analgesic properties of psychotridinePhytomedicine8(3)202-206(2001)

Betamethasone 21-phosphate is a synthetic glucocorticoid.1It prevents increases in macrophage and eosinophil numbers in bronchoalveolar lavage fluid (BALF) and decreases in blood leukocyte numbers in a guinea pig model of parainfluenza-3 viral infection when administered at a dose of 8 mg/kg but does not prevent airway hyperresponsiveness after infection.2Betamethasone 21-phosphate inhibits cell infiltration into the aqueous humor in a rat model of endotoxin-induced uveitis when administered topically or subcutaneously at doses of 0.01-1% or 1 mg/kg, respectively.3It increases maximal lung pressure volume curves in fetal sheep when administered to pregnant ewes at 0.75 gestation at doses of 80 and 170 μg/kg.1Betamethasone 21-phosphate increases body weight, impairs learning and memory, increases anxiolytic behavior, and reduces hippocampal neurogenesis in CD-1 mice but reduces body weight and increases neurogenesis with no effect on anxiety in high-anxiety DBA/2 mice when administered at a dose of approximately 25 mg/kg per day in the drinking water for seven weeks.4Formulations containing betamethasone 12-phosphate and betamethasone acetate have been used in the treatment of severe allergic conditions and a variety of immune-related conditions. 1.Loehle, M., Schwab, M., Kadner, S., et al.Dose-response effects of betamethasone on maturation of the fetal sheep lungAm. J. Obstet. Gynecol.202(2)186.e181-186.e187(2010) 2.Leusink-Muis, A., Ten Broeke, R., Folkerts, G., et al.Betamethasone prevents virus-induced airway inflammation but not airway hyperresponsiveness in guinea pigsClin. Exp. Allergy29(Suppl. 2)82-85(1999) 3.Tsuji, F., Sawa, K., Kato, M., et al.The effects of betamethasone derivatives on endotoxin-induced uveitis in ratExp. Eye Res.64(1)31-36(1997) 4.Aiello, R., Crupi, R., Leo, A., et al.Long-term betamethasone 21-phosphate disodium treatment has distinct effects in CD1 and DBA/2 mice on animal behavior accompanied by opposite effects on neurogenesisBehav. Brain Res.278155-166(2015)