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  • 抑制剂&激动剂
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    TargetMol | Inhibitors_Agonists
  • Tamibarotene
    NSC 608000, 他米巴罗汀, Am 80, Amnolake
    T669494497-51-5
    Tamibarotene (Amnolake) 是一种具有口服活性的合成维甲酸,旨在克服全反式维甲酸耐药性,具有潜在的抗肿瘤活性。它也是视黄酸受体α β 的激动剂,比RARγ的选择性高。
    • ¥ 283
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  • Previridicatumtoxin
    T370061379585-81-5
    Previridicatumtoxin is a fungal metabolite that has been found inP. aethiopicumand has diverse biological activities.1,2It is an intermediate in the biosynthesis of the mycotoxin viridicatumtoxin . Previridicatumtoxin is active against methicillin-resistantS. aureus(MRSA) and vancomycin-resistantE. faecalis(IC50s = 4.4 and 4.8 μM, respectively), as well asC. albicansandS. cerevisiae(MIC = 32 μg ml for both).2,1It is cytotoxic to NCI H460, KB-3-1, and SW620 cancer cells (IC50s = 5.3, 4.1, and 6 μM, respectively).2 1.Chooi, Y.H., Wang, P., Fang, J., et al.Discovery and characterization of a group of fungal polycyclic polyketide prenyltransferasesJ. Am. Chem. Soc.134(22)9428-9437(2012) 2.Shang, Z., Salim, A.A., Khalil, Z., et al.Viridicatumtoxins: Expanding on a rare tetracycline antibiotic scaffoldJ. Org. Chem.80(24)12501-12508(2015)
    • ¥ 2484
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