aktin3

AKT-IN-3 is a potent, orally active low hERG blocking Akt inhibitor (IC50: 1.4 nM, 1.2 nM, and 1.7 nM for Akt1, Akt2, and Akt3). AKT-IN-3 (compound E22) also exhibits good inhibitory activity against other AGC family kinases, such as PKA, PKC, ROCK1, RSK1

PI3K AKT-IN-3（化合物 8C）通过抑制 PI3K AKT 信号途径，可有效诱导自噬与细胞凋亡。该化合物主要应用于癌症相关的研究领域。