aβ-in-1 tfa

Aβ-IN-1 TFA 能够抑制和逆转不同类型的蛋白质聚集。

Verubecestat TFA, also known as MK-8931 or SCH 900931, is a potent and selective beta-secretase inhibitor, and BACE1 protein inhibitor or Beta-site APP-cleaving enzyme 1 inhibitor. Verubecestat TFA is a promising novel therapeutic drug candidate in Alzheimer's disease. Verubecestat TFA reduced Aβ cerebral spinal fluids (CSF) levels up to 92% and was well tolerated by patients.

LPYFD-NH2 TFA, 作为一种五肽, 具有抑制Aβ(1-42)聚集的功能, 适用于阿兹海默症的研究。

焦谷氨酸修饰的 Amyloid β-Protein (3-42) TFA，通称为 pEAβ (3-42)，扮演了阿兹海默症中淀粉样斑块形成的关键角色。作为 Pyr 肽的前体，这种变体能够加速 Aβ(1-42) 的聚集过程，而 Aβ(1-42) 则在抑制 pEAβ(3-42) 的初级及次级成核过程中起到显著作用。