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Search Results for " spermidine "

15

抑制剂 & 化合物

11

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T31554	DNA-Spermidine DA-51,DA 51,DA51,DNA Spermidine
	DNA-spermidine influences the activity of restricted endonuclease from several bacterial species.
T69600	Spermidine-d6
	Spermidine-d6 is intended for use as an internal standard for the quantification of spermidine by GC- or LC-MS. Spermidine is an endogenous polyamine. It is formed from putrescine by spermidine synthase. Spermidine (25 µM) inhibits the activity of the human inward-rectifying potassium channel Kir2.3 in a patch-clamp assay. It induces autophagy in HeLa cells when used at a concentration of 100 µM and increases the lifespan of D. melanogaster, yeast, and C. elegans. Spermidine (30 mM in the drinki...
T37170	N1-Acetylspermidine hydrochloride N1-Acetylspermidine (hydrochloride)	Endogenous Metabolite	Metabolism
	N1-Acetylspermidine hydrochloride 是亚精胺的乙酰基衍生物。 N1-Acetylspermidine hydrochloride 是多胺氧化酶的底物，可选择性地提高其在人结直肠腺癌中的水平。
T19461	N1,N8-Diacetylspermidine	Endogenous Metabolite	Metabolism
	N1,N8-Diacetylspermidine 是人尿中的一种多胺。N1,N8-Diacetylspermidine 可用作癌症和恶性肿瘤的标记物。
T19460	N1,N8-Diacetylspermidine hydrochloride	Others	Others
	N1,N8-Diacetylspermidine hydrochloride is a polyamines in the human urine.
T74655	Glutathionylspermidine
	Glutathionylspermidine 是一种多肽，也是大肠杆菌代谢物。
T30196	Atherospermidine
	Atherospermidine is a smooth muscle relaxant aporphines from Artabotrys maingayi.
T9640	Diethylnorspermine HCl Diethylnorspermine tetrahydrochloride,N1,N11-Diethylnorspermine tetrahydrochloride,DENSPM tetrahydrochloride	Others	Others
	Diethylnorspermine HCl (N1,N11-Diethylnorspermine tetrahydrochloride) 可有效诱导 SSAT (亚精胺/精胺N1-乙酰转移酶) mRNA，并有效稳定 SSAT 酶活性。
T74696	SpdSyn binder-1	Parasite	Microbiology/Virology
	SpdSyn binder-1 是一种弱结合剂，结合在恶性疟原虫亚精胺合酶的活性位点，对疟疾有部分抑制作用，可用于研究疟疾。
T32255	Jam 2-263 Jam 2 263l,Jam-2-263,Jam2263
	Jam 2-263 is a spermidine-based catechol ferric carrier - carbocephalosporin.
T74932	Trypanothione synthetase-IN-1
	Trypanothione synthetase-IN-1 (Compound 1) 为一竞争性婴儿利什曼虫锥体胱甘肽合成酶(TryS)抑制剂，以三胺亚精胺为多胺S时，IC50值为14.8 μM。
T70805	Diethylnorspermine HBr
	Diethylnorspermine, also known as DENSPM, BE-333, DE-333 and N(1),N(11)-Diethylnorspermine, is a highly potent known inducer of the polyamine catabolic enzyme, spermidine/spermine N1-acetyltransferase (SSAT). A designed polyamines (PAs) analog which induces cell cycle arrest, inhibits proliferation and induces apoptosis in melanoma, breast, prostate, lung and colon cancer cells..
T74933	Trypanothione synthetase-IN-2
	Trypanothione synthetase-IN-2 (Compound 3) 为竞争性婴儿利什曼虫锥虫胱甘肽合成酶 (TryS) 抑制剂，以三胺亚精胺作为多胺S时，IC50 值为5.4 μM。
T70049	Ro 04-5595 free base
	Ro 04-5595 is a selective antagonist of NMDA receptors NR2B subunits. Ro 04-5595 had an EC 50 of 186 ± 32 nmol/L. Ro 04-5595 was predicted to bind the EVT-101 binding site, not the ifenprodil-binding site. Specific binding, defined with a new NR2B-specific antagonist Ro 04-5595 at 10 microM was fully inhibited by several compounds with the following rank order of affinities--Ro 25-6981 > CP-101,606 > Ro 04-5595 = ifenprodil >> eliprodil > haloperidol > spermine > spermidine > MgCl2 > CaCl2--and...
T60348	N1,N11-Diethylnorspermine
	N1,N11-Diethylnorspermine (DENSPM) 是一种有效的抗癌剂。N1,N11-Diethylnorspermine 是一种精胺类似物,可激活多胺分解代谢。N1,N11-Diethylnorspermine 诱导细胞色素 c 从线粒体中释放，导致 caspase 3的激活。N1,N11-Diethylnorspermine 通过诱导亚精胺/精胺 N1- 乙酰转移酶 (SSAT) 结合产生过氧化氢杀灭多形胶质母细胞瘤 (GBM) 细胞。

化合物

DNA-Spermidine

Cat.No: T31554

Synonym: DA-51,DA 51,DA51,DNA Spermidine

Spermidine-d6

Cat.No: T69600

N1-Acetylspermidine hydrochloride

Cat.No: T37170

Synonym: N1-Acetylspermidine (hydrochloride)

Target: Endogenous Metabolite

N1,N8-Diacetylspermidine

Cat.No: T19461

Target: Endogenous Metabolite

N1,N8-Diacetylspermidine hydrochloride

Cat.No: T19460

Target: Others

Glutathionylspermidine

Cat.No: T74655

Atherospermidine

Cat.No: T30196

Diethylnorspermine HCl

Cat.No: T9640

Synonym: Diethylnorspermine tetrahydrochloride,N1,N11-Diethylnorspermine tetrahydrochloride,DENSPM tetrahydrochloride

Target: Others

SpdSyn binder-1

Cat.No: T74696

Target: Parasite

Cat.No: T32255

Synonym: Jam 2 263l,Jam-2-263,Jam2263

Trypanothione synthetase-IN-1

Cat.No: T74932

Diethylnorspermine HBr

Cat.No: T70805

Trypanothione synthetase-IN-2

Cat.No: T74933

Ro 04-5595 free base

Cat.No: T70049

N1,N11-Diethylnorspermine

Cat.No: T60348

Cat. No.	Product Name	Target	Signaling Pathways
T4893	Spermidine N-(3-Aminopropyl)-1,4-diaminobutane,亚精胺,N-(4-Aminobutyl)-1,3-diaminopropane	Endogenous Metabolite	Metabolism
	Spermidine (N-(3-Aminopropyl)-1,4-diaminobutane) 能够维持细胞膜稳定性，提高抗氧化酶活性，改善光系统 II 以及相关基因表达。它结合并激活 NMDA，并已显示以浓度依赖性方式增强 NMDA 诱导的电流。
T5080	Spermidine trihydrochloride Spermidine hydrochloride,4-Azaoctamethylenediamine trihydrochloride,三盐酸亚精胺,亚精胺盐酸盐	NMDAR; Autophagy	Autophagy; Neuroscience
	Spermidine trihydrochloride (4-Azaoctamethylenediamine trihydrochloride) 能够维持细胞膜稳定性，提高抗氧化酶特性，改善光系统 II (PSII) 以及相关基因表达，也能够显著抑制 H2O2和 O2.-含量。
TN6088	tricoumaroyl spermidine N1,N5,N10-(Z)-tri-p-coumaroylspermidine,N1,N5,N10-(E)-Tri-p-coumaroylspermidine,N1,N5,N10-Tri-p-coumaroylspermidine	5-HT Receptor	GPCR/G Protein; Neuroscience
	Tricoumaroyl spermidine(N1,N5,N10-(Z)-tri-p-coumaroylspermidine) 被发现是一种独特的茶(Camellia sinensis) 花代谢物。
TN4621	N1,N10-Bis(p-coumaroyl)spermidine	Glucosidase	Metabolism
	N1,N10-Bis(p-coumaroyl)spermidine 对α-葡萄糖苷酶有抑制作用，可从苜蓿的草本植物中提取。
T80937	Tris(dihydrocaffeoyl)spermidine
	Tris(dihydrocaffeoyl)spermidine为活性化合物，从马铃薯(Solanum tuberosum)块茎中分离得到，主要用于代谢研究。
T81717	N1-Dihydrocaffeoyl, N10-caffeoyl spermidine
	N1-Dihydrocaffeoyl, N10-caffeoyl spermidine为源自Lycium ruthenicum Murr.的天然化合物，可通过分离提取得到。
T19466	N8-Acetylspermidine dihydrochloride N8-乙酰基亚精胺二盐酸盐	Endogenous Metabolite	Metabolism
	N8-Acetylspermidine dihydrochloride 是一种多胺物质。
TN6556	Safflospermidine B
	Safflospermidine B is a potential natural tyrosinase inhibitor, it shows high antityrosinase activity (IC50 of 31.8μM).
TN6553	N1,N5,N10-(E)-tri-p-coumaroylspermidine
	N1,N5,N10-(E)-tri-p-coumaroylspermidine shows free radical-scavenging activity.
TN6555	Safflospermidine A
	Safflospermidine A is a potential natural tyrosinase inhibitor,it shows high antityrosinase activity (IC50 of 13.8 μM).
T3007	Spermine Gerontine,Musculamine,精胺,4,9-Diaza-1,12-dodecanediamine,NSC 268508,Neuridine	Influenza Virus; Endogenous Metabolite	Metabolism; Microbiology/Virology
	Spermine (Neuridine) 作为一个直接的自由基清除剂，具有抗病毒作用，能够保护 DNA 免受自由基的攻击。

天然产物

Cat.No: T4893

Synonym: N-(3-Aminopropyl)-1,4-diaminobutane,亚精胺,N-(4-Aminobutyl)-1,3-diaminopropane

Target: Endogenous Metabolite

Spermidine trihydrochloride

Cat.No: T5080

Synonym: Spermidine hydrochloride,4-Azaoctamethylenediamine trihydrochloride,三盐酸亚精胺,亚精胺盐酸盐

Target: NMDAR, Autophagy

tricoumaroyl spermidine

Cat.No: TN6088

Synonym: N1,N5,N10-(Z)-tri-p-coumaroylspermidine,N1,N5,N10-(E)-Tri-p-coumaroylspermidine,N1,N5,N10-Tri-p-coumaroylspermidine

Target: 5-HT Receptor

N1,N10-Bis(p-coumaroyl)spermidine

Cat.No: TN4621

Target: Glucosidase

Tris(dihydrocaffeoyl)spermidine

Cat.No: T80937

N1-Dihydrocaffeoyl, N10-caffeoyl spermidine

Cat.No: T81717

N8-Acetylspermidine dihydrochloride

Cat.No: T19466

Synonym: N8-乙酰基亚精胺二盐酸盐

Target: Endogenous Metabolite

Safflospermidine B

Cat.No: TN6556

N1,N5,N10-(E)-tri-p-coumaroylspermidine

Cat.No: TN6553

Safflospermidine A

Cat.No: TN6555

Cat.No: T3007

Synonym: Gerontine,Musculamine,精胺,4,9-Diaza-1,12-dodecanediamine,NSC 268508,Neuridine

Target: Influenza Virus, Endogenous Metabolite

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