691
77
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T32826 |
LNA-Adenosine
LNA-A,LNA Adenosine,2'-O,4'-C-Methyleneadenosine |
Nucleoside Antimetabolite/Analog | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
LNA-Adenosine (LNA-A) 是一种核苷类似物,可作为作为腺苷A3受体配体。 | |||
T23636 |
Adenosine N1-oxide
ANO,1-Oxoadenosine,Adenosine N1 oxide,Adenosine, 1-oxide,腺苷氮氧化物 |
Immunology/Inflammation related | Immunology/Inflammation |
Adenosine N1-oxide (1-Oxoadenosine) 是在蜂王浆中发现的腺苷 N1-氧化物,可抑制活化的巨噬细胞分泌炎症介质,并降低脂多糖 (LPS) 诱导的内毒素休克的致死率。 | |||
T22231 |
Adenosine Dialdehyde (ADOX)
腺苷二醛,Periodate-oxidized adenosine,Adenosine, periodate oxidized,Adenox,Adenosinedialdehyde |
Others | Others |
Adenosine Dialdehyde (Periodate-oxidized adenosine) 是嘌呤核苷类似物,是S-腺苷高半胱氨酸水解酶(SAHH)的有效抑制剂(Ki=3.3nM)。Adenosine Dialdehyde 在体内具有较强的抗肿瘤活性。 | |||
T65979 |
Adenosine 5'-monophosphate disodium salt
Adenosine Phosphate Disodium,5‘-AMP-NA2 |
Nucleoside Antimetabolite/Analog | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Adenosine 5'-monophosphate disodium salt (Adenosine Phosphate Disodium) 是一种参与 ATP 代谢的嘌呤核苷酸,用于研究 ATP 对细胞和生物体的影响。Adenosine 5'-monophosphate disodium salt 已被证明具有多种生化和生理作用,它可以促进细胞代谢、基因表达和蛋白质合成。 | |||
T10247 |
Adenosine 5'-diphosphoribose sodium
Adenosine 5'-diphosphoribose sodium,ADP ribose sodium |
Endogenous Metabolite; TRP/TRPV Channel; Autophagy | Autophagy; Membrane transporter/Ion channel; Metabolism |
Adenosine 5'-diphosphoribose sodium (ADP ribose sodium) 是一种烟酰胺腺嘌呤核苷酸 (NAD+) 的代谢产物,广泛存在于生物体内。Adenosine 5'-diphosphoribose sodium (ADP ribose sodium) 是一种高效的细胞内 Ca2+ 渗透性阳离子 TRPM2 通道激活剂,还可以诱导自噬 (autophagy)。 | |||
T7683 |
Adenosine amine congener
ADAC |
Adenosine Receptor | GPCR/G Protein; Neuroscience |
Adenosine amine congener (ADAC) 是一种选择性的 A1 腺苷受体激动剂,具有神经保护作用,可以改善噪音和顺铂引起的耳蜗损伤。 | |||
T10248 |
Adenosine antagonist-1
|
Adenosine Receptor | GPCR/G Protein; Neuroscience |
Adenosine antagonist-1 可作为一种腺苷 A3 受体 (AA3R) 拮抗剂。 | |||
T12163 |
N6-(2-Phenylethyl)adenosine
N6-Phenethyladenosine,N6-Phenylethyladenosine |
Adenosine Receptor | GPCR/G Protein; Neuroscience |
N6-(2-Phenylethyl)adenosine (N6-Phenethyladenosine) 是一种腺苷衍生物和腺苷受体激动剂,对大鼠和人 A1 的 Ki 值分别为 11.8 nM 和 30.1 nM。 | |||
T60103 |
N6-(p-Hydroxyphenethyl)-Adenosine)
|
Others | Others |
N6-(p-Hydroxyphenethyl)-Adenosine) 是一种腺苷类似物。 | |||
T14127 |
Adenosine A1 receptor activator T62
|
Adenosine Receptor | GPCR/G Protein; Neuroscience |
Adenosine A1 receptor activator T62 是腺苷 A1 受体的变构增强剂,有镇痛作用。 | |||
T22466 |
Adenosine receptor A1 antagonist 5
|
cAMP | GPCR/G Protein |
Adenosine receptor A1 antagonist 5 可作为一种腺苷拮抗剂,是一种氧嘌呤,可作为杀虫剂和虫害防治剂,对血压升高有抑制作用。 | |||
T21620 |
Adenosine receptor antagonist 4
|
Adenosine Receptor | GPCR/G Protein; Neuroscience |
Adenosine receptor antagonist 4 是一种腺苷受体拮抗剂。 | |||
T60020 |
5'-Fluoro-5'-deoxyadenosine
5'-Fluoro-5'-deoxy-adenosine |
Others | Others |
5'-Fluoro-5'-deoxyadenosine (5'-Fluoro-5'-deoxy-adenosine) 常用作研究放线菌卡特链霉菌的工具。 | |||
T29347 |
2-Ethynyl Adenosine
2-Ethynyl-Ade,2 Ethynyl Adenosine,2-Ethynyl-Adenosine |
||
2-Ethynyl Adenosine is an Adenosine derivative that is used to capture novel polyadenylated transcription and non-radiochemical reporter molecules of the protein AMPylation. | |||
T16325 |
NITD008
7-Deaza-2'-C-acetylene-adenosine |
Others | Others |
NITD008 (7-Deaza-2'-C-acetylene-adenosine) 是一种有效的和选择性的腺苷核苷抑制剂,是一种腺苷核苷类似物,具有广谱的抗病毒活性,抑制登革热病毒、动物杯状病毒和寨卡病毒。 | |||
T39011 |
N6-Benzyl-5'-ethylcarboxamido adenosine
N6-Benzyl-5'-ethylcarboxamido adenosine |
||
N6-Benzyl-5'-ethylcarboxamido adenosine is a selective A3 adenosine receptor agonist. | |||
T38449 |
Guanosine 5'-triphosphate-5'-adenosine
GpppA,Guanosine 5'-triphosphate-5'-adenosine |
||
Guanosine 5'-triphosphate-5'-adenosine, the 5′ cap analog, is a fluorescent substrate analog. | |||
T10212 |
A2AR-agonist-1
N-(2-(1H-Indol-3-yl)ethyl)adenosine |
Others; Adenosine Receptor | GPCR/G Protein; Neuroscience; Others |
A2AR-agonist-1 (N-(2-(1H-Indol-3-yl)ethyl)adenosine)是一种有效的 A2AR 和 ENT1激动剂, Ki 值 分别为 4.39 μM 和 3.47 μM。 | |||
T40721 |
N7-Methyl-guanosine-5'-triphosphate-5'-adenosine
N7-Methyl-guanosine-5'-triphosphate-5'-adenosine,m7GpppA |
||
N7-Methylguanosine-5'-triphosphate-5'-adenosine (m7GpppA) is a dinucleotide cap analog employed in the process of in vitro RNA transcription. | |||
T83827 |
Adenosine-5'-O-(3-thiotriphosphate) sodium
ATPγS,Adenosine 5'-(γ-thio)-triphosphate |
||
Adenosine-5'-O-(3-thiotriphosphate)(ATPγS)是一种purinergic P2Y11受体的激动剂。在表达人类或犬类P2Y11受体的CHO-K1细胞中,能够诱导肌醇磷酸累积(EC50s分别为1.2和19.3 µM)。ATPγS(10 µM)能抑制Junin病毒导致的编码骨形态生成蛋白6(BMP6)的mRNA水平增加,并减少Junin病毒感染的初代大鼠成骨细胞中的粒子形成单位(PFUs)。使用25 µM浓度时,可以诱导MIN6胰岛β细胞分泌胰岛素。 | |||
T35573 | Adenosine 5’-methylenediphosphate (hydrate) | ||
Adenosine 5’-methylenediphosphate is an inhibitor of ecto-5’-nucleotidase, also known as CD73, with a Kivalue of 37 nM.1It inhibits cAMP accumulation induced by adenosine 5’-monophosphate , adenosine 5’-diphosphate , or adenosine 5’-triphosphate but not adenosine in VA-13 human fibroblasts when used at a concentration of 100 μM. Adenosine 5’-methylenediphosphate reduces proliferation of U138MG glioma cells, as well as inhibits the invasion and migration of MHCC97H hepatocellular carcinoma (HCC) ... | |||
TNU0429 |
N6-(2-Hydroxyethyl)adenosine
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
N6-(2-Hydroxyethyl)adenosine 是一种 Ca2+拮抗剂和抗炎剂,与脑和冠状动脉循环的控制有关,被认为具有镇静活性。 | |||
T19179 |
Adenosine deaminase
|
Others | Others |
Adenosine deaminase is an enzyme that catalyzes the irreversible deamination of 2'-deoxyadenosine and adenosine to 2'-deoxyinosine and inosine, respectively. | |||
TNU0178 |
2'-O-(2-Azidoethyl)adenosine
|
Nucleoside Antimetabolite/Analog | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
2'-O-(2-Azidoethyl)adenosine 是一种嘌呤核苷类似物,具有潜在的抗肿瘤活性。2’-O-(2-Azidoethyl)adenosine 的活性与抑制DNA合成和凋亡有关。 | |||
T40307 |
Adenosine receptor antagonist 1
|
||
Adenosine receptor antagonist 1 is a highly selective antagonist for the A2aR adenosine receptor, exhibiting an IC50 value of 0.29 nM. It demonstrates a remarkable 14-fold selectivity towards the A2aR receptor in comparison to the A2bR receptor. | |||
T38416 | Adenosine 5'-succinate | ||
Adenosine 5'-succinate is a compound closely related to adenosine monophosphate (AMP) that demonstrates strong inhibitory properties against taste receptor activation of transducin caused by Denatonium benzoate. | |||
T35574 |
Adenosine 5'-phosphosulfate (sodium salt)
|
||
Adenosine 5'-phosphosulfate is an ATP and sulfate competitive inhibitor of ATP sulfurylase in humans, S. cerevisiae, and P. chrysogenum (Ki = 18, 2500, and 1500 nM, respectively). Adenosine 5'-phosphosulfate also inhibits human adenosine 5'-phosphosulfate kinase (Ki = 47.5 μM) to prevent sulfation. | |||
T35571 | Adenosine 3’-monophosphate (sodium salt hydrate) | ||
Adenosine 3’-monophosphate is a nucleotide and metabolite formedviahydrolysis of 2’,3’-cAMP by metal-dependent phosphodiesterases.1It reduces proliferation of rat preglomerular vascular smooth muscles cells (PGVSMCs) and glomerular mesangial cells (GMCs) in a concentration-dependent manner, an effect that is abolished by the adenosine A2Breceptor antagonist MRS1754.2Adenosine 3’-monophosphate is also a metabolic intermediate in the biosynthesis of adenosine . | |||
T71927 |
Adenosine-5'-diphosphate disodium salt
|
||
Adenosine 5'-diphosphate disodium salt has been shown to inhibit the binding of serotonin (5-hydroxytryptamine) to 5-HT2 receptors, which are present in heart tissue. | |||
T22554 |
Adenosine Kinase Inhibitor (hydrate)
|
Others | Others |
Adenosine kinase is the key metabolizing enzyme regulating cellular adenosine concentrations. Inhibition of adenosine kinase can selectively enhance the protective actions of adenosine during tissue trauma without producing the nonspecific effects associa | |||
T16166 |
N-[(4-Aminophenyl)methyl]adenosine
|
AMPK | Chromatin/Epigenetic; PI3K/Akt/mTOR signaling |
N-[(4-Aminophenyl)methyl]adenosine is an adenosine receptor inhibitor (Ki: 29 nM for Rat ecto-5′-Nucleotidase). | |||
T12159 |
APNEA
(2R,3R,4S,5R)-2-[6-[2-(4-aminophenyl)ethylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol,N6-[2-(4-Aminophenyl)ethyl]adenosine,N6-[2-(4-氨基苯基)乙基]腺嘌呤 |
Adenosine Receptor | GPCR/G Protein; Neuroscience |
APNEA ((2R,3R,4S,5R)-2-[6-[2-(4-aminophenyl)ethylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol) 是腺苷 A3 受体的非选择性激动剂。 | |||
T35572 |
Adenosine 3',5'-diphosphate sodium salt
3'-Phosphoadenosine 5'-phosphate |
Endogenous Metabolite | Metabolism |
Adenosine 3',5'-diphosphate sodium salt 是一种羟类固醇磺基转移酶 (hydroxysteroid sulfotransferases) 抑制剂,是一种腺嘌呤核苷酸,在戊糖核糖的 3'和 5'位置含有一个磷酸基团。Adenosine 3',5'-diphosphate (sodium salt)是 3'-phosphoadenosine 5'-phosphosulfonate (PAPS) 的产物,是磺基转移酶(SULTs)的辅助因子,已被用于研究 SULTs 的动力学特性和结构。 | |||
T37146 |
5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine
|
||
5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine, an adenosine derivative, serves as an intermediate in the synthesis of oligonucleotides. | |||
T65008 |
L-Adenosine
|
||
L-Adenosine 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T65008,CAS号为 3080-29-3。 | |||
TNU1637 |
alpha-Adenosine
|
||
alpha-Adenosine 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 TNU1637,CAS号为 5682-25-7。 | |||
TNU0298 |
Adenosine-2-carboxamide
|
||
Nucleoside Derivatives - 2-Modified purine nucleosides | |||
T37118 |
ADP-Glucose (sodium salt)
ADPG,Adenosine-5'-diphosphoglucose,ADP-Glucose (sodium salt) |
||
ADP-Glucose (ADPG) is an immediate precursor used in the biosynthesis, by glucose addition, of storage polysaccharides in plants, green algae, and cyanobacteria, as well as structural polysaccharides in certain bacteria.[1],[2] It is used by amylose synthases or starch synthases in plastids in the production of amylose, amylopectins, starch, and other polysaccharides. ADPG is normally generated within plastids, although it can be biosynthesized in the cytoplasm of certain grasses and imported in... | |||
T16136 |
MRS-1706
|
Adenosine Receptor | GPCR/G Protein; Neuroscience |
MRS-1706 是一种选择性A2B 腺苷受体的反向激动剂,对人 A2B、A2A、A1和 A3受体的Ki 值分别为 1.39、112、157 和 230 nM。 | |||
TNU1117 | 2-Diethoxymethyl adenosine | ||
2-Diethoxymethyl adenosine 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 TNU1117。 | |||
TNU0465 | 2-Aminomethyl adenosine | ||
Nucleoside Derivatives - 2-Modified purine nucleosides | |||
TNU0327 | 2-Trifluoromethyl adenosine | ||
Nucleoside Derivatives –8-substituted purine nucleosides ;ara-nucleosides. | |||
T12008 |
MethADP
Adenosine 5'-(α,β-methylene)diphosphate |
Others | Others |
MethADP is a specific inhibitor of CD73. | |||
TNU1650 | 3’-O-Hexadecanyl adenosine | ||
3’-O-Hexadecanyl adenosine 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 TNU1650。 | |||
TNU0860 |
N6-Acetyl adenosine
|
||
Nucleoside Derivatives –Naturally modified ribo-nucleosides;Other modified nucleosides | |||
TNU0337 | Adenosine 2-amidine hydrochloride | ||
Nucleoside Derivatives - 2-Modified purine nucleosides; | |||
TNU0398 |
8-Methylthio-adenosine
|
||
Nucleoside Derivatives - 8-Modified purine nucleosides | |||
T75208 | 2-Diethoxymethyl adenosine | ||
2-Diethoxymethyl adenosine 是一种腺嘌呤核苷类似物。腺苷类似物大多可作为平滑肌血管扩张剂,也被证明能够抑制癌症进展。它的热门产品有 Adenosine phosphate,Acadesine ,Clofarabine ,Fludarabine phosphate 和 Vidarabine 。 | |||
TNU0341 | N6-(2-Propynyl)adenosine | ||
Nucleoside Derivatives - 6-Modified purine nucleosides | |||
T8551 |
Nitrobenzylthioinosine
NBMPR,S-(4-硝基苄基)-6-硫代肌苷 |
AChR; Adenosine Receptor | GPCR/G Protein; Neuroscience |
Nitrobenzylthioinosine (NBMPR) 是一种 ENT1 转运蛋白抑制剂,可与 ENT1 转运蛋白以高亲和力结合。它是一种可穿过血脑屏障的光亲和探针,用于追踪大脑中腺苷的摄取位点。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T0853 |
Adenosine
腺苷,D-Adenosine,Adenine riboside |
Apoptosis; Nucleoside Antimetabolite/Analog; Endogenous Metabolite; Autophagy | Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism |
Adenosine (D-Adenosine) 是一种核糖核苷,由与核糖结合的腺嘌呤组成,具有血管扩张、抗心律失常和镇痛作用。 | |||
T1723 |
Adenosine 5'-diphosphate
腺苷5'-二磷酸,Adenosine diphosphate,adenosine pyrophosphate,ADP |
Endogenous Metabolite | Metabolism |
Adenosine 5'-diphosphate (ADP) 是一种嘌呤核糖核苷5'-二磷酸,是 ATP 在 ATP 酶作用下去磷酸化的产物。Adenosine 5'-diphosphate (adenosine pyrophosphate) 可诱导人血小板聚集并通过作用于P2T-嘌呤受体抑制受刺激的腺苷酸环化酶。 | |||
T2133 |
Adenosine monophosphate
5'-Adenylic acid,5'-腺嘌呤核苷酸,AMP,Adenosine 5'-monophosphate |
Endogenous Metabolite; AMPK | Chromatin/Epigenetic; Metabolism; PI3K/Akt/mTOR signaling |
Adenosine monophosphate (AMP) 是一种嘌呤核糖核苷5'-单磷酸腺苷,是信号转导和调节能量稳态的关键细胞代谢物。它具有EC 3.1.3.11(果糖-二磷酸酶)抑制剂、EC 3.1.3.1(碱性磷酸酶)抑制剂和腺苷A1受体激动剂的作用。 | |||
T5079 |
Adenosine 5'-diphosphate sodium salt
腺苷-5‘-二磷酸钠盐,Adenosine-5'-diphosphate trisodium salt,ADP sodium salt |
Others; Endogenous Metabolite | Metabolism; Others |
Adenosine 5'-diphosphate sodium salt (ADP sodium salt) 是一种核苷二磷酸,是一种 ATP 酶对 ATP 去磷酸化的产物。它通过在 P2T-嘌呤受体上的作用诱导人血小板聚集并抑制刺激的腺苷酸环化酶。 | |||
T12164 |
N6-(4-Hydroxybenzyl)adenosine
Para-topolin riboside,N6-羟苄腺苷 |
P2Y Receptor | GPCR/G Protein; Neuroscience |
N6-(4-Hydroxybenzyl)adenosine (Para-topolin riboside) 是一种血小板聚集抑制剂。 | |||
T0853L |
Adenosine 5'-monophosphate monohydrate
5'-AMP,腺苷-5'-单磷酸一水合物,5'-AMP monohydrate,5'-Adenylic acid |
AMPK; Adenosine Receptor; HSV | Chromatin/Epigenetic; GPCR/G Protein; Microbiology/Virology; Neuroscience; PI3K/Akt/mTOR signaling |
Adenosine 5'-monophosphate monohydrate (5'-AMP) 是一种核苷酸,用作 RNA 中的单体。它是一个腺苷 A1受体激动剂,对HSV-1和HSV-2具有显著的抗病毒活性。 | |||
T34698 |
Spongosine
2-Methoxy adenosine |
Others | Others |
Spongosine (2-Methoxy adenosine) 是一种重要的细胞间信号递质,具有多种生物活性,包括抗炎活性、镇痛和血管舒张特性。Spongosine 是从海洋生物中分离出来的天然产物,于1950年首次从海洋海绵隐毛隐(Cryptotethia crypta)中分离出来。 | |||
T64980 |
ATP disodium trihydrate
Adenosine-5'-triphosphate disodium trihydrate |
Endogenous Metabolite | Metabolism |
ATP disodium trihydrate (Adenosine-5'-triphosphate disodium trihydrate) 是体内能量储存和代谢的重要物质,是免疫和炎症中重要的内源性信号分子,可为机体代谢提供能量,同时在细胞中作为辅酶发挥作用。 | |||
T20089 |
ATP
Atipi,ATP disodium salt hydrate,Triphosphoric acid adenosine ester,Ara-ATP,Triphosphaden,Adenosine triphosphate;Ara-ATP,Adenosine triphosphate |
Endogenous Metabolite | Metabolism |
ATP (Adenosine triphosphate) 可为细胞提供能量,参与整体能量平衡,维持细胞内稳态。ATP 可以通过与特异性嘌呤能受体的相互作用充当细胞外信号分子,以介导神经传递、炎症、细胞凋亡和骨重塑等多种过程。 | |||
TCO2745 |
Cyclic AMP
Adenosine 3',5'-cyclophosphate,cAMP,腺苷环磷酸酯,环磷腺苷,Cyclic 3',5'-monophosphate adenosine,3',5'-AMP,Adenosine Cyclophosphate |
Others; Endogenous Metabolite | Metabolism; Others |
Cyclic AMP (cAMP)(Adenosine 3',5'-cyclophosphate) 是有丝分裂信使,可以促进 G1期到 S 期的细胞周期进程。 | |||
TN7208 |
2-Methyladenosine
2-methyl adenosine,2-甲基腺苷 |
Others | Others |
2-Methyladenosine (2-methyl adenosine) 是一种海洋来源的天然产物,存在于Family Tethyidae。 | |||
T1352 |
ATP disodium salt
Adenosine 5'-triphosphate disodium salt,三磷酸腺苷二钠,ATP,ATP disodium,腺苷-5'-三磷酸二钠盐,Adetide,Adenosine-Triphosphate,Disodium adenosine triphosphate |
P2X Receptor; Endogenous Metabolite | Membrane transporter/Ion channel; Metabolism; Neuroscience |
ATP disodium salt (Adenosine-Triphosphate) 是体内能量储存的重要物质,为代谢提供能量,同时在细胞中作为辅酶发挥作用。Adenosine 5'-triphosphate disodium salt 也是免疫和炎症中重要的内源性信号分子。 | |||
T2812 |
ATP disodium salt hydrate
ATP disodium,ATP disodium salt,Adenosine disodium triphosphate,三磷酸腺苷二钠盐 |
Others; Endogenous Metabolite | Metabolism; Others |
ATP disodium salt hydrate (Adenosine disodium triphosphate) 是体内能量储存和代谢的重要物质,为代谢提供能量,同时在细胞中作为辅酶发挥作用。同时,它是也是免疫和炎症中重要的内源性信号分子。 | |||
T38415 | Adenosine 5′-monophosphoramidate sodium | ||
Adenosine 5′-monophosphoramidate sodium is a derivative of adenosine used as an intermediate for nucleotide synthesis. It significantly influences the accumulation of cyclic AMP. | |||
T39025 | Adenosine 2',5'-diphosphate sodium | ||
Adenosine 2',5'-diphosphate sodium is a competitive P2Y1 antagonist with non-selective antagonism at recombinant and human platelet P2X1 receptors. | |||
T20054 |
Adenosine-2'-monophosphate
2'-Adenylic acid |
||
2'-Adenylic acid is an agent of bioactive chemical. | |||
T8227 |
5'-Methylthioadenosine
Methylthioadenosine,5-脱氧-5-甲硫腺苷,5'-(Methylthio)-5'-deoxyadenosine,5'-Deoxy-5'-(methylthio)adenosine,5'-S-Methyl-5'-thioadenosine |
Endogenous Metabolite | Metabolism |
5'-Methylthioadenosine (Methylthioadenosine) 是由 S-腺苷蛋氨酸在多胺合成过程中生成的核苷,通过抑制肿瘤细胞增殖、侵袭和诱导细胞凋亡来抑制肿瘤,同时控制肿瘤组织的炎症微环境。 | |||
TN2247 |
Swertisin
|
Adenosine Receptor | GPCR/G Protein; Neuroscience |
Swertisin 是从日本紫菜中分离出的 C-葡萄糖基黄酮,是腺苷 A1 受体拮抗剂,具有抗糖尿病、抗炎和抗氧化作用。 | |||
T0437 |
Inosine
INO 495,NSC 20262,肌苷 |
ROS; Endogenous Metabolite; Adenosine Receptor | GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience |
Inosine (NSC-20262) 是由腺苷分解代谢产生的一种内源性嘌呤核苷,是腺苷受体A1R 和A2AR 的激动剂,具有抗炎免疫调节,抗伤害和神经保护作用。 | |||
TN1736 |
Hibifolin
棉皮素-8-O-Β-D-葡萄糖醛酸苷,棉花皮素-8-O-葡萄糖醛酸苷 |
Adenosine deaminase | Metabolism |
Hibifolin 是一种黄酮醇糖苷,是潜在的腺苷脱氨酶抑制剂。它可以保护神经元免受 beta-淀粉样蛋白诱导的毒性。 | |||
T1681 |
Aminophylline
氨茶碱,Phyllocontin |
PDE; Adenosine Receptor | GPCR/G Protein; Metabolism; Neuroscience |
Aminophylline (Phyllocontin) 是一种竞争性非选择性磷酸二酯酶抑制剂,具有支气管扩张作用。它是竞争性的腺苷受体拮抗剂,有用于哮喘研究的潜力。 | |||
T0892 |
Diphylline
二羟丙茶碱,Dyphylline,Diprophylline |
PDE; Adenosine Receptor | GPCR/G Protein; Metabolism; Neuroscience |
Diphylline (Diprophylline) 是一种A1/A2腺苷受体拮抗剂,也是环状核苷酸磷酸二酯酶抑制剂。它是一种黄嘌呤衍生物,具有支气管扩张和血管扩张作用,有用于治疗慢性支气管炎和肺气肿的潜力。 | |||
T5940 |
Proxyphylline
羟丙茶碱,7-(2-Hydroxypropyl)theophylline |
PDE; Adenosine Receptor | GPCR/G Protein; Metabolism; Neuroscience |
Proxyphylline (7-(2-Hydroxypropyl)theophylline) 是甲基黄嘌呤衍生物,可用作心脏活化剂、血管扩张剂和支气管扩张剂。 | |||
T5S1895 |
Norisoboldine
Laurelliptine,去甲异波尔定,(+)-Laurelliptine |
MAPK; Adenosine Receptor | GPCR/G Protein; MAPK; Neuroscience |
Norisoboldine ((+)-Laurelliptine) 是一种可口服的芳基烃受体激动剂,是乌药中主要的异喹啉类生物碱,可用于类风湿性关节炎和溃疡性结肠炎的研究。 | |||
T0625 |
Theobromine
3, 7-Dimethylxanthine,可可碱,3,7-Dimethylxanthine |
Endogenous Metabolite; PDE; Adenosine Receptor | GPCR/G Protein; Metabolism; Neuroscience |
Theobromine (3,7-Dimethylxanthine) 是在可可豆中发现的一种甲基黄嘌呤,抑制腺苷受体 A1 信号传导,用作支气管扩张剂和血管扩张剂。 | |||
T0480 |
Doxofylline
Doxophylline,多索茶碱 |
PDE; Adenosine Receptor | GPCR/G Protein; Metabolism; Neuroscience |
Doxofylline (Doxophylline) 是腺苷 A1 受体拮抗剂,且能抑制磷酸二酯酶 IV,用于治疗哮喘。 | |||
T1083 |
Theophylline
Theo-24,1,3-Dimethylxanthine,茶碱 |
Endogenous Metabolite; HDAC; PDE; Adenosine Receptor; Autophagy | Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; GPCR/G Protein; Metabolism; Neuroscience |
Theophylline (1,3-Dimethylxanthine) 是茶中的甲基黄嘌呤衍生物,具有利尿、平滑肌松弛、支气管扩张、心脏和中枢神经系统兴奋作用。 | |||
T2205 |
Acefylline
Theophylline-7-acetic acid,茶碱乙酸,Carboxymethyltheophylline,acetyloxytheophylline,Theophyllineacetic acid |
TNF; PAD; PKA; HDAC; PDE; Adenosine Receptor | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; GPCR/G Protein; Metabolism; Neuroscience; Tyrosine Kinase/Adaptors |
Acefylline (Theophylline-7-acetic acid) 是黄嘌呤衍生物,是一种腺苷受体拮抗剂。它是蛋白质精氨酸脱亚氨酶 (PAD) 激活剂,也是一种支气管扩张剂,可抑制大鼠肺 cAMP 磷酸二酯酶同工酶。 | |||
T17143 |
Toyocamycin
丰加霉素,Vengicide |
Apoptosis; Others; IRE1; Antibiotic; Antifungal | Apoptosis; Cell Cycle/Checkpoint; Microbiology/Virology; Others |
Toyocamycin (Vengicide) 是放线菌类产生的腺苷类似物,为 X 盒结合蛋白 1 (XBP1) 抑制剂,抑制 IRE1α 诱导的 ATP 依赖性 XBP1 mRNA 的断裂,IC50值为 80 nM。它还诱导凋亡。 | |||
T40370 |
2′-Deoxyadenosine 5′-monophosphate disodium
|
Endogenous Metabolite | Metabolism |
2′-Deoxyadenosine 5′-monophosphate disodium, a nucleic acid AMP derivative, is a deoxyribonucleotide present in DNA. It is employed for researching adenosine-based interactions within DNA synthesis and damage analysis. | |||
T13482 |
2'-O-Methyladenosine
|
Endogenous Metabolite | Metabolism |
2'-O-Methyladenosine 是甲基化腺嘌呤的残基,在正常人群和腺苷脱氨基酶缺乏病人的尿液中均可被检测到。它显示出独特的降血压活性。 | |||
T2752 |
2'-Deoxyadenosine monohydrate
|
Others; Endogenous Metabolite | Metabolism; Others |
2'-Deoxyadenosine monohydrate 是化学合成中的砌块,是一种脱氧核糖核苷。 | |||
T4737 |
2'-Deoxyadenosine-5'-monophosphate
D-AMP,2′-脱氧腺苷-5′-单磷酸,2'-Deoxyadenosine 5'-monophosphate,2'-脱氧腺苷-5'-单磷酸 |
Others; Endogenous Metabolite | Metabolism; Others |
2'-Deoxyadenosine-5'-monophosphate (D-AMP) 是一种存在于 DNA 中的脱氧核糖核苷酸,是一种核酸 AMP 衍生物。它能够用于研究 DNA 合成和 DNA 损伤过程中基于腺苷的相互作用。 | |||
T6599 |
N6-methyladenosine
N6-甲基腺苷,N-Methyladenosine,6-Methyladenosine,NSC-29409,m6A |
Others; Influenza Virus; Endogenous Metabolite | Metabolism; Microbiology/Virology; Others |
N6-methyladenosine (NSC-29409) 是甲基化的腺嘌呤残基,苷是转移核糖核酸降解的内源性尿核苷产物。它是存在于所有高等真核生物中普遍的的信使 RNA 内部修饰,可修饰病毒 RNA,有抗病毒活性。 | |||
T7981 |
2-Fluoroadenosine
|
Others | Others |
2-Fluoroadenosine 是淋巴细胞介导的细胞溶解的有效抑制剂。 | |||
T20041 |
2'-Deoxyadenosine
2'-脱氧腺苷,NSC-141848,NSC141848,NSC 141848 |
Endogenous Metabolite | Metabolism |
2'-Deoxyadenosine (NSC-141848) 是核苷腺苷的一种衍生物,能够与双链 DNA 中的脱氧胸苷配对。 | |||
T4971 |
5'-DEOXYADENOSINE
5′-dAdo,5-脱氧腺嘌呤核苷 |
Endogenous Metabolite | Metabolism |
5'-Deoxyadenosine (5′-dAdo) 是正常受试者尿液中发现的氧化核苷,氧化核苷代表了用于确定遗传物质损伤程度的生物标志物。 | |||
T7571 |
1-Methyladenosine
|
Endogenous Metabolite | Metabolism |
1-Methyladenosine 是 RNA 修饰,主要来自两种不同的反应类型,酶催化反应以及 RNA 与某些烷化剂反应。 | |||
T37635 |
2'-Deoxyadenosine-5'-triphosphate trisodium
dATP trisodium |
DNA/RNA Synthesis; Endogenous Metabolite | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism |
2'-Deoxyadenosine-5'-triphosphate trisodium (dATP trisodium) 是一种核苷酸,是 DNA 聚合酶的底物,在细胞中用于 DNA 合成或复制。 | |||
T36667 |
2'-Deoxyadenosine-5'-triphosphate
dATP,Deoxyadenosine 5-triphosphate |
DNA/RNA Synthesis; Endogenous Metabolite | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism |
2'-Deoxyadenosine-5'-triphosphate (Deoxyadenosine 5-triphosphate) (dATP) 是一种天然存在的小分子核苷酸,在细胞中用于DNA合成或复制。2'-Deoxyadenosine-5'-triphosphate (dATP) 是 DNA 聚合酶的底物。2'-Deoxyadenosine-5'-triphosphate 通过无活性的 α4beta4 四级结构抑制RNA。2'-Deoxyadenosine-5'-triphosphate 与心肌细胞生长有关。 | |||
T83789 |
7-Deazaadenosine-5'-O-diphosphate sodium
7-CH-ADP,Tubercidin 5’-diphosphate,TuDP |
||
7-Deazaadenosine-5'-O-diphosphate是一种修饰过的核苷酸和tubercidin的代谢物。该化合物通过磷酸化tubercidin形成,并进一步磷酸化生成活性代谢物7-deazaadenosine-5'-O-triphosphate。 | |||
T40483 |
8-Aminoadenosine
8-NH2-Ado,8-氨基腺苷 |
||
8-Aminoadenosine (8-NH2-Ado) is an RNA-directed nucleoside analogue that effectively diminishes cellular ATP levels and impedes mRNA synthesis. Furthermore, it effectively obstructs Akt/mTOR signaling, inducing autophagy and apoptosis in a p53-independent manner. Its significant antitumor activity further highlights its therapeutic potential. | |||
T37977 |
Succinyladenosine
|
||
Succinyladenosine is a biochemical marker of adenylosuccinase (ASL) deficiency. It is formed through the dephosphorylation of intracellular adenylosuccinic acid (S-AMP) by cytosolic 5-nucleotidase [1]. | |||
T7327 |
7-Methoxyisoflavone
|
AMPK | Chromatin/Epigenetic; PI3K/Akt/mTOR signaling |
7-Methoxyisoflavone 是单磷酸腺苷活化蛋白激酶 (AMPK) 的激活剂,是异黄酮衍生物。 | |||
T14149 |
AICAR phosphate
AICA Riboside phosphate,Acadesine phosphate |
Mitophagy; NOS; YAP; AMPK | Autophagy; Chromatin/Epigenetic; Immunology/Inflammation; PI3K/Akt/mTOR signaling; Stem Cells |
AICAR phosphate (Acadesine phosphate) 是 AMPK 激活剂且是自噬、YAP 和 mitophagy 抑制剂,也是一种腺苷类似物, 可调节糖代谢和脂代谢,抑制促炎细胞因子和 iNOS 的产生。 | |||
T10822 |
Cirsimarin
Cirsitakaoside |
Adenosine Receptor | GPCR/G Protein; Neuroscience |
Cirsimarin (Cirsitakaoside) 是一种从 Microtea debilis 中分离出来的黄酮类化合物。它具有很强的抗脂肪生成作用,能减少小鼠脂肪组织的沉积。Cirsimarin 对腺苷 A1 受体有拮抗作用,对磷酸二酯酶有抑制作用 | |||
T3S0156 |
Atractyloside potassium salt
Atractyloside Dipotassium Salt,苍术苷钾盐,苍术苷二钾盐 |
Others | Others |
Atractyloside potassium salt (Atractyloside Dipotassium Salt) 是一种从苍术果实中分离出得到的二萜苷类化合物,具有毒性。它能抑制大鼠心脏线粒体膜的氯离子通道。它是高效、特异性的线粒体 ADP/ATP 转运 (ADP/ATP transport) 抑制剂。 | |||
T4S0792 |
Pinoresinol 4-O-β-D-glucopyranoside
(+)-pinor,(+)-pinoresinol-β-D-glucoside; (+)-pinor,(+)-pinoresinol-β-D-glucoside |
Others | Others |
(+)-pinoresinol-β-D-glucoside; (+)-pinor 是连翘中主要的活性呋喃类木脂素。它显示出抗氧化、降血压和环磷酸腺苷 (cAMP) 磷酸二酯酶抑制活性。 | |||
T1609 |
NAD+
烟酰胺腺嘌呤二核苷酸,Cozymase,煙酸胺,β-DPN,DPN,β-Nicotinamide Adenine Dinucleotide,β-NAD |
NADPH; Endogenous Metabolite | Metabolism |
NAD+ (β-Nicotinamide Adenine Dinucleotide) 即烟酰胺腺嘌呤二核苷酸,是转递氢离子的辅酶。 | |||
T0974 |
Novobiocin Sodium
Albamycinsodium,新生霉素钠,Cathomycin,Albamycin |
Potassium Channel; DNA gyrase; Topoisomerase; Antibacterial; Antibiotic; ABC; Autophagy | Autophagy; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology |
Novobiocin Sodium (Albamycinsodium) 是源自 Streptomyces niveus 的抗生素。 它的化学结构类似于香豆素。Novobiocin 与 DNA 促旋酶结合并阻断三磷酸腺苷活性。 | |||
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