187 1, n wasp inhibitor

Inhibits neural Wiskott-Aldrich syndrome protein (N-WASP) by stabilizing the autoinhibited state of the protein. Blocks phosphatidylinositol 4,5-bisphosphate (PIP2)-stimulated actin assembly (IC50 ~ 2 μM) but does not directly inhibit actin polymerization

187-1, N-WASP inhibitor TFA，一种14-aa 环肽及N-WASP 抑制剂，能有效阻止由磷脂酰肌醇 4,5-二磷酸酯 (PIP2) 触发的肌动蛋白装配，IC50 值达 2 μM。该化合物通过维持蛋白质自身的抑制状态，进而抑制N-WASP 激活Arp2 3 复合体。