1,3-dimethylxanthine-d6

Paraxanthine-D6 is intended for use as an internal standard for the quantification of paraxanthine by GC- or LC-MS. Paraxanthine (T4973) is an active metabolite of caffeine. It is formed via N3-demethylation of caffeine by the cytochrome P450 (CYP) isoform CYP1A2. Paraxanthine (T4973) is an adenosine A1 and A2 receptor antagonist. In vivo,paraxanthine increases striatal cGMP and extracellular striatal dopamine levels and locomotor activity,as well as inhibits motor depression induced by the adenosine A1 agonist CPA or the adenosine A2 receptor agonist CGS 21680 in rats not habituated to caffeine. It also promotes wakefulness and increases locomotor activity and core temperature in narcoleptic transgenic mice without increasing behavioral anxiety.

Paraxanthine (1,7-dimethylxanthine) 是一种 caffeine 的代谢物，能够刺激Ryanodine 受体通道来抑制多巴胺能细胞的死亡。

Paraxanthine-D6 (Standard) 是 Paraxanthine-D6 的标准品，适用于定量分析、质量控制及生化实验等相关研究。Paraxanthine-d6 用于作为通过气相色谱-质谱法（GC-MS）或液相色谱-质谱法（LC-MS）定量测定Paraxanthine的内标物质。Paraxanthine是咖啡因的一种活性代谢产物。